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DOI: 10.1055/s-2002-33804
© Georg Thieme Verlag Stuttgart · New York
Saccopetrins A and B, Two Novel γ-Lactones from Saccopetalum prolificum
Publication History
Received: October 2, 2001
Accepted: March 17, 2002
Publication Date:
09 September 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200208/lookinside/thumbnails/10.1055-s-2002-33804-1.jpg)
Abstract
Two new γ-lactones, saccopetrin A (1) and saccopetrin B (2), together with 10 known compounds have been isolated from the roots of Saccopetalum prolificum. Their structures were established by spectroscopic and chemical methods. The absolute configuration of 1 was determined by chemical transformation and the Mosher method. Cytotoxic activities were evaluated against several different cell lines. Compound 2 exhibited stronger cytotoxic activities than 1 against KB and HCT-8 cell lines at a concentration of 10-5 mol/L.
Key words
Annonaceae - Saccopetalum prolificum - acetogenin-γ-lactones - saccopetrin A - saccopetrin B
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Prof. De-Quan Yu
Institute of Materia Medica
Chinese Academy of Medical Sciences
Peking Union Medical College
Beijing, 100050
People’s Republic of China
Email: dqyu@imm.ac.cn
Fax: +86-10-63017757