Subscribe to RSS
DOI: 10.1055/s-2002-33480
Behandlung der Schuppenflechte mit Interferenzstrom Elektromagnetische Therapie auf neuen Wegen
Treatment of Psoriasis with Interferential Current - New Perspectives of Electromagnetic TherapyPublication History
Publication Date:
22 August 2002 (online)
![](https://www.thieme-connect.de/media/derma/200205/lookinside/thumbnails/10.1055-s-2002-33480-1.jpg)
Zusammenfassung
Wir berichten zunächst über die klinisch erfolgreiche Therapie der Psoriasis mit Interferenzstrom, einer Stromform, die traditionell in der Physiotherapie Anwendung findet. Zielmolekül der Behandlung ist das zyklische AMP. Auf der Grundlage von Ergebnissen mit Zellen, die in vitro behandelt wurden, wird gezeigt, dass die Menge dieses zellulären Botenstoffes bei bestimmten Modulationsfrequenzen des Interferenzstroms hoch reguliert werden kann. Interessante Perspektiven für eine Ausdehnung elektromagnetischer Therapien auf andere Krankheitsbilder ergeben sich aus neueren Publikationen. Wir geben einen kurzen Überblick über Ergebnisse von Untersuchungen in vitro und an Tiermodellen, die zeigen, dass insbesondere magnetische Wechsel- oder Pulsfelder Prozesse wie Angiogenese, Chaperon-Induktion oder neuronale Differenzierung stimulieren können.
Abstract
We report on the clinically successful therapy of psoriasis with Interferential Current, a wave form traditionally applied in physiotherapy. The therapeutic strategy focusses on cyclic AMP as target molecule. Based on results with cells exposed in vitro it is shown that the amount of this cellular messenger can be upregulated at specific modulation frequencies of Interferential Current. Interesting perspectives for extending electromagnetic therapy to other diseases emerge from recent publications. We provide a short review of results from investigations in vitro and on animal models which show that, in particular alternating or pulsed magnetic fields, may stimulate processes like angiogenesis, chaperon induction and neuronal differentiation.
Literatur
- 1 Albertini A, Zucchini P, Noera G, Cadossi R, Napaleone C P, Pierangeli A. Protective effect of low frequency low energy pulsing electromagnetic fields on acute experimental myocardial infarcts in rats. Bioelectromagnetics. 1999; 20 372-377
- 2 Asadullah K, Friedrich N, Hanneken S, Rohrbach C, Audring H, Vergopoulos A, Ebeling M, Docke W D, Volk H D. Effects of systemic interleukin-10 therapy on psoriatic skin lesions: histologic, immunobiologic, and molecular biology findings. J Invest Dermatol. 2001; 116 721-727
- 3 Carmody S, Wu X L, Lin H, Blank M, Skopicki H, Goodman R. Cytoprotection by electromagnetic field-induced hsp70: a model for clinical application. J Cell Biochem. 2000; 79 453-459
- 4 Das N S, Chowdary T N, Sobhanadri C, Rao K V. The effect of topical isoprenaline on psoriatic skin. Brit J Dermatol. 1978; 99 197-200
- 5 Eigler A, Siegmund B, Emmerich U, Baumann K H, Hartmann G, Endres S. Anti-inflammatory activities of cAMP-enhancing agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production. J Leukoc Biol. 1998; 63 101-107
- 6 Feria-Velasco A, Castillo-Medina S, Verdugo-Diaz L, Castellanos E, Orozco-Suarez S, Sanchez-Gomez C, Drucker-Colin R. Neuronal differentiation of chromaffin cells in vitro induced by extremely low frequency magnetic fields or nerve growth factor: a histological and ultrastructural comparative study. J Neurosci Res. 1998; 53 569-582
- 7 Gottwald E, Wobus A M, Guan K, Sontag W, Weibezahn K F, Dertinger H. Interferential electric field treatment revealed a low increase of spontaneous cardiac differentiation but no cyclic AMP changes nor induction of cardiac-specific gene expression in pluripotent embryonal carcinoma P19 cells. Electromagnetic Biology And Medicine. 2002; 21(2) 105-118
- 8 Grant G, Cadossi R, Steinberg G. Protection against focal cerebral ischemia following exposure to a pulsed electromagnetic field. Bioelectromagnetics. 1994; 15 205-216
- 9 Kanno S, Oda N, Abe M, Saito S, Hori K, Handa Y, Tabayaschi K, Sato Y. Establishment of a simple and practical procedure applicable to therapeutic angiogenesis. Circulation. 1999; 25 2682-2687
- 10 Knedlitschek G, Noszvai-Nagy M, Meyer-Waarden H, Schimmelpfeng J, Weibezahn K F, Dertinger H. Cyclic AMP response in cells exposed to electric fields of different frequencies and intensities. Radiat Environm Biophys. 1994; 33 141-147
- 11 Lin H, Opler M, Head M, Blank M, Goodman R. Electromagnetic field exposure induces rapid, transitory heat shock factor activation in human cells. J Cell Biochem. 1997; 66 482-488
- 12 Macias M Y, Battocietti J H, Sutton C H, Pintar F A, Maiman D J. Directed and enhanced neurite growth with pulsed magnetic field stimulation. Bioelectromagnetics. 2000; 21 272-286
- 13 Philipp A, Wolf G K, Rzany B, Dertinger H, Jung E G. Interferential current is effective in palmar psoriasis: an open prospective trial. Eur J Dermatol. 2000; 10 195-198
- 14 Pipkin J L, Hinson W G, Young J F, Rowland K L, Shaddock J G, Tolleson W H, Duffy P H, Casciano D A. Induction of stress proteins by electromagnetic fields in cultured HL-60 cells. Bioelectromagnetics. 1999; 20 347-357
- 15 Platzer C, Meisel C, Vogt K, Platzer M, Volk H D. Up-regulation of monocytic IL-10 by tumor necrosis factor-alpha and cAMP elevating drugs. Int Immunol. 1995; 7 517-523
- 16 Post A, Müller M B, Engelmann M, Keck M E. Repetitive transcranial magnetic stimulation in rats: evidence for a neuroprotective effect in vitro and in vivo. Eur J Neurosci. 1999; 11 3247-3254
- 17 Royer E, Chaintreul J, Meynadier J, Michel B, Guilhou J J, Crastes de Paulet A. Cyclic AMP and cyclic GMP production in normal and psoriatic epidermis. Dermatologica. 1982; 165 533-543
- 18 Sauer H, Rahimi G, Hescheler J, Wartenberg M. Effects of electrical fields on cardiomyocyte differentiation of embryonic stem cells. J Cell Biochem. 1999; 75 710-723
- 19 Sontag W, Dertinger H. Response of cytosolic calcium, cyclic AMP and cyclic GMP in dimethylsulfoxide-differentiated HL-60 cells to modulated low frequency electric currents. Bioelectromagnetics. 1998; 19 452-458
- 20 Tao Q, Henderson A. EMF induces differentiation in HL-60 cells. J Cell Biochem. 1999; 73 212-217
- 21 Voorhees J J, Duell E A. Imbalanced cyclic AMP - cyclic GMP levels in psoriasis. Adv Cyclic Nucleotide Res. 1975; 5 735-758
- 22 Yen-Patton G P, Patton W F, Beer D M, Jacobson B S. Endothelian cell response to pulsed electromagnetic fields: stimulation of growth rate and angiogenesis in vitro. J Cell Physiol. 1988; 134 37-46
Prof. Dr. H. Dertinger
Forschungszentrum Karlsruhe · Institut für Medizintechnik und Biophysik
Postfach 3640 · 76021 Karlsruhe