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Synthesis 2002(10): 1373-1378
DOI: 10.1055/s-2002-33118
DOI: 10.1055/s-2002-33118
PAPER
© Georg Thieme Verlag Stuttgart · New York
A Practical Route to a Complex Bis-Steroidal Diene Intermediate Using a Microwave Assisted Heck-Reaction
Weitere Informationen
Received
30 November 2002
Publikationsdatum:
01. August 2002 (online)
Publikationsverlauf
Publikationsdatum:
01. August 2002 (online)
![](https://www.thieme-connect.de/media/synthesis/200210/lookinside/thumbnails/10.1055-s-2002-33118-1.jpg)
Abstract
A very special set of Heck-conditions led reliably to a non-symmetric bis-steroidal diene which underwent regioselective high-pressure Diels-Alder cycloadditions with non-symmetric electron poor acetylenes. The cyclohexadienes thus obtained were aromatized to the corresponding benzene derivatives.
Key words
natural products - Heck reaction - microwave conditions - Diels-Alder reactions - regioselectivity
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