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Synthesis 2002(10): 1359-1364
DOI: 10.1055/s-2002-33117
DOI: 10.1055/s-2002-33117
PAPER
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Chiral n,n+1-Diamino Acids and their Application to the Construction of Dendrimers
Further Information
Received
28 January 2002
Publication Date:
01 August 2002 (online)
Publication History
Publication Date:
01 August 2002 (online)
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Abstract
Efficient methods for the synthesis of chiral n,n+1-diamino acids starting from l-glutamic acid were developed. A second generation prototype amino acid based dendrimer, containing 1,3-propanediamine as the core and 4,5-diaminopentanoic acid as the branching unit, was synthesised following the divergent approach. Diaminobutane poly(propyleneimine) dendrimers modified at the periphery with n,n+1-diamino acids were synthesized and characterized.
Key words
amides - amino acids - azides - coupling - dendrimers
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