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Synthesis 2002(10): 1379-1384
DOI: 10.1055/s-2002-33106
DOI: 10.1055/s-2002-33106
PAPER
© Georg Thieme Verlag Stuttgart · New York
A Facile Access to 2-CF3-Imidazo[1,2-a]pyridines
Further Information
Received
10 April 2001
Publication Date:
01 August 2002 (online)
Publication History
Publication Date:
01 August 2002 (online)
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Abstract
A new simple and efficient way to 2-CF3-imidazo[1,2-a]pyridines and 2-CF3-imidazo[1,2-a]quinolines by the reaction of 1,1,1-trifluoro-4-(phenylsulfonyl)but-3-ene-2,2-diols 1a,b with various 2-aminopyridines is described. The cyclization reaction proceeds diastereospecifically under mild conditions in water.
Key words
diastereoselectivity - cycloaddition - heterocycles - imidazo[1,2-a]pyridines - imidazo[1,2-a]quinolines - sulfones
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