Synlett 2002(8): 1296-1298
DOI: 10.1055/s-2002-32964
LETTER
© Georg Thieme Verlag Stuttgart · New York

Single-Pass Reaction Column System with Super Brønsted Acid-loaded Resin

Kazuaki Ishihara, Aiko Hasegawa, Hisashi Yamamoto*
Graduate School of Engineering, Nagoya University, SORST, Japan Science and Technology Corporation (JST), Furo-cho, Chikusa, Nagoya 464-8603, Japan
Fax: +81(52)7893222; e-Mail: yamamoto@cc.nagoya-u.ac.jp;
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Publikationsverlauf

Received 9 May 2002
Publikationsdatum:
25. Juli 2002 (online)

Abstract

Various acid-promoted reactions gave the desired products in high yields by passing a solution of reactants through a reaction column packed with polystyrene-bound super Brønsted acid (1) just once. Polar and nonpolar organic solvent-swellable 1 is much superior to Nafion® SAC-13 (2) as a Brønsted acid-loaded resin packed in the column.

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It was ascertained that Celite® 545 itself did not catalyze any reactions which were demonstrated in this paper by blank experiments without 1.