Mururins A-C, Three New Lignoids from Brosimum acutifolium and their Protein Kinase Inhibitory Activity

Abstract

Two new flavonolignans, mururins A and B (1 and 2), and a new lignan, mururin C (3), were isolated from the bark of Brosimum acutifolium Huber together with three known lignans. Their structures were elucidated by spectroscopic means and chemical modifications. They were tested for protein kinase A (PKA) and protein kinase C (PKC) inhibitory activity. Mururin A showed 3 % and 63 % inhibition to PKA and PKC, respectively, at 20 μM. Mururin B showed 58 % and 38 % inhibition, respectively. Mururin C did not have significant activity.

Key words

Brosimum acutifolium - Moraceae - flavonolignans - lignan - protein kinase A - protein kinase C

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