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Planta Med 2002; 68(7): 626-630
DOI: 10.1055/s-2002-32899
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Sesquiterpene Lactone Glycosides, Eudesmanolides, and Other Constituents from Carpesium macrocephalum

Chao Yang1 , Yan-Ping Shi2 , Zhong-Jian Jia1
  • 1Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, P.R. China
  • 2Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, P.R. China
Further Information

Publication History

Received: October 5, 2001

Accepted: February 3, 2002

Publication Date:
22 July 2002 (online)

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Abstract

Two new sesquiterpene lactone glycosides and two new eudesmanolides, along with twelve known compounds were isolated from seeds of Carpesium macrocephalum. The structures of these new compounds were elucidated as 2α-O-β-D-glucopyranosyl-5α, 11αH-eudesma-4(15)-en-12,8β-olide (1), 2α-O-β-D-glucopyranosyl-5αH-eudesma-4(15),11(13)-dien-12,8β-olide (2), 2α-acetoxy-5α-hydroxy-11αH-eudesma-4(15)-en-12,8β-olide (3) and 2α,5α-dihydroxy-11αH-eudesma-4(15)-en-12,8β-olide (4) by spectroscopic methods including 2D NMR techniques (1H-1H COSY, 1H-1H NOESY, HMQC, HMBC) and chemical transformations. Compounds 1, 6, 8, 9 and 10 exhibited moderate antibacterial activity, while compound 4 showed appreciable cytotoxic activity against cultured SMMC-7721 (human hepatoma cell).

Key words

Carpesium macrocephalum - Compositae - eudesmanolide - sesquiterpene lactone glycosides - antibacterial activity - cytotoxic activity

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Prof. Zhong-Jian Jia

Department of Chemistry

Lanzhou University

Lanzhou, Gansu 730000


Peoples Republic of China

Email: Zhengrl@lzu.edu.cn

Fax: + 86-0931-8 912 582

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