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DOI: 10.1055/s-2002-32570
© Georg Thieme Verlag Stuttgart · New York
Antiulcerogenic Activity of Some Sesquiterpene Lactones Isolated from Artemisia annua
Publikationsverlauf
August 24, 2001
March 23, 2002
Publikationsdatum:
01. Juli 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200206/lookinside/thumbnails/10.1055-s-2002-32570-1.jpg)
Abstract
Artemisinin 1, dihydro-epideoxyarteannuin B 2 and deoxyartemisinin 3 were isolated from the sequiterpene lactone-enriched fraction obtained from the crude ethanolic extract of Artemisia annua L. These compounds were tested on ethanol and indomethacin-induced ulcer models. Compound 1 did not afford cytoprotection under the experimental models tested. Only compounds 2 and 3 decreased the ulcerative lesion index produced by ethanol and indomethacin in rats. These compounds did not demonstrate antiulcerogenic activity when tested on the ethanol-induced ulcer model, with previous administration of indomethacin, suggesting that the antiulcerogenic activity is a consequence of prostaglandin synthesis increase.
Key words
Artemisia annua - Asteraceae - antiulcer activity - sesquiterpenes
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