Planta Med 2002; 68(6): 558-561
DOI: 10.1055/s-2002-32565
Letter
© Georg Thieme Verlag Stuttgart · New York

Aceriphyllic Acid A, A New ACAT Inhibitory Triterpenoid, from Aceriphyllum rossii

Jae-Taek Han1 , Hae-Yeong Kim1 , Young-Doo Park1 , Youn-Hyung Lee1 , Kang-Ro Lee2 , Byoung-Mog Kwon3 , Nam-In Baek1
  • 1Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University, Suwon, Korea
  • 2College of Pharmacy, Sung Kyun Kwan University, Suwon, Korea
  • 3Korea Research Institute of Bioscience & Biotechnology, Taejeon, Korea
Further Information

Publication History

September 20, 2001

February 3, 2002

Publication Date:
01 July 2002 (online)

Abstract

Two new triterpenoids along with three known ones, 3-oxoolean-12-en-27-oic acid (1), 3α-hydroxyolean-12-en-27-oic acid (2) and 3β-hydroxyolean-12-en-27-oic acid (3), were isolated from Aceriphyllum rossii. The structures of the new compounds were determined to be a 3α,23-dihydroxyolean-12-en-27-oic acid (4) and a 3α,23-dihydroxyolean-12-en-29-oic acid (5) by spectroscopic and chemical methods; they were designated aceriphyllic acids A and B, respectively. Compounds 2, 3 and 4 remarkably inhibited the activity of ACAT.

References

  • 1 Chen T K, Ales D C, Baenziger N C, Wiemer D F. Ant-repellent triterpenoids from Cordia alliodora .  J. Org. Chem.. 1983;  48 3525-31
  • 2 Takahashi K, Kanayama K, Tanabe Y, Takani M. Studies of constituents of medicinal plants. XI. Constituents of the roots of Astilbe thunbergii M. var congests H. B.  Chem. Pharm. Bull.. 1972;  20 2106-10
  • 3 Taipale H T, Veps linen J, Latikainen P, Reichhardt P B, Lapinjoki S P. Isolation and structure determination of three triterpenes from bark of juvenile European white birch.  Phytochemistry. 1993;  34 755-8
  • 4 Izawa K, Nagai M, Inoue T. Triterpene acids and bergenin in Peltoboykinia watanabei and Boykinia lycoctonifolia .  Phytochemistry. 1973;  12 1508
  • 5 Kaneda N, Pezzuto J M, Kinghorn A D, Farnsworth N R. Plant anticancer agents, L. cytotoxic triterpenes from Sandoricum koetjape stems.  J. Nat. Prod.. 1992;  55 654-9
  • 6 Yasuhara M, Saito K, Kubota H, Ohmizu H, Suzuki Y. Inhibitory effect of a new ureidophenol derivative T-2591 on LDL oxidation and ACAT activity.  Biol. Pharm. Bull. 1997;  20 1056-60
  • 7 Yotsumoto H, Yanagita T, Yamamoto K, Ogawa Y, Cha J Y, Mori Y. Inhibitory effects of Oren-Gedoku-To and its components on cholesteryl ester synthesis in cultured human hepatocyte HepG2 cells: Evidence from the cultured HepG2 cells and in vitro assay of ACAT.  Planta Medica. 1997;  63 141-5

Nam-In Baek

Graduate School of Biotechnology

Kyun Hee University

Seochun-Ri 1

Kiheung-Eup

Yongin-Si

Kyunggi-Do 449-701

Korea

Phone: +82-31-201-2661

Fax: +82-31-204-8116

Email: nibaek@ khu.ac.kr