Planta Med 2002; 68(6): 554-556
DOI: 10.1055/s-2002-32555
Letter
© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Constituents from Aquilegia ecalcarata

Si-Bao Chen1 , Guang-Yao Gao1 , Ye-Shi Li2 , Shi-Chun Yu2 , Pei- Gen Xiao1
  • 1Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, P. R. China
  • 2AnHui An-Tech Medicine & Biological Technology Co. LTD, Heifei, P. R. China
Further Information

Publication History

July 31, 2001

January 12, 2002

Publication Date:
01 July 2002 (online)

Abstract

A new alkaloid, 7-hydroxy-4-(5′-hydroxymethylfuran-2′-yl)-2-quinolone (1), and a new nitrile derivative, 3α,4β-dihydroxy-6-oxo-1-cyclohexene-1-acetonitrile (2), together with three known oxoaporphine alkaloids, were isolated from the whole plant of Aquilegia ecalcarata. Their structures were established on the basis of spectral evidence. Their in vitro cytotoxicity against different classes of cancer cell lines, including GLC-82 and HCT were determined. The new alkaloid 1 [IC50 (GLC-82) 8.8 ± 0.2 μM, IC50 (HCT) 10.1 ± 0.3 μM] and hernandonine (3) [IC50 (GLC-82) 7.6 ± 0.5 μM, IC50 (HCT) 8.2 ± 0.5 μM] exhibited cytotoxicity towards the cancer cell lines.

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Dr. Si-Bao Chen

Research and Development Division

School of Chinese Medicine

Hong Kong Baptist University

Kowloon Tong

Hong Kong

Email: chensibao@hotmail.com

Fax: (+852) 2339-5571