Planta Med 2002; 68(6): 568-569
DOI: 10.1055/s-2002-32553
Letter
© Georg Thieme Verlag Stuttgart · New York

A New Diterpene from Tanaecium jaroba

Anne-Claire Mitaine-Offer1 , Michel Sauvain2 , Eric Deharo2 , Victoria Muñoz3 , Monique Zèches-Hanrot1
  • 1Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université de Reims Champagne-Ardenne, Reims, France
  • 2Institut de Recherche pour le Développement (IRD), Paris, France
  • 3Instituto Boliviano de Biología de Altura, Universidad Mayor de San Andres, La Paz, Bolivia
Weitere Informationen

Publikationsverlauf

November 9, 2001

December 9, 2001

Publikationsdatum:
01. Juli 2002 (online)

Abstract

One new diterpene, 2α-hydroxy-12ß-hydroxy-isopimara-8(14), 15-diene, and six known compounds as triterpenes, sterols and fatty acid, were isolated from the stem bark of Tanaecium jaroba (Bignoniaceae), a Bolivian plant used in traditional medicine. Their structures were established mainly by 1D and 2D NMR (COSY, HMQC, HMBC, ROESY) and their antiplasmodial activities were evaluated in vitro against Plasmodium falciparum.

References

  • 1 Muñoz V, Sauvain M, Bourdy G, Callapa J, Bergeron S, Rojas I, Bravo J A, Balderrama L, Ortiz B, Gimenez A, Deharo E. A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part I. Evaluation of the antimalarial activity of plants used by the Chacobo Indians.  J. Ethnopharmacol.. 2000;  69 127-37
  • 2 Tanaka Y, Sato H. Sequence distribution of cis-1,4- and trans-1,4-units in polyisoprenes.  Polymer. 1976;  17 113-6
  • 3 Patra A, Mukhopadhyay A K, Mitra A. Carbon-13 resonance assignments of some friedelanes and taraxasteranes.  Org. Magn. Reson.. 1981;  17 166-8
  • 4 Nozaki H, Suzuki H, Hirayama T, Kasai R, Wu R -J, Lee K -H. Antitumour triterpenes of Maytenus diversifolia .  Phytochemistry. 1986;  25 479-85
  • 5 Betancor C, Freire R, Gonzalez A G, Salazar J A, Pascard C, Prange T. Three triterpenes and other terpenoids from Catha cassinoides .  Phytochemistry. 1980;  19 1989-93
  • 6 Guerriero A, D’Ambrosio M, Pietra F, Debitus C, Ribes O. Pteridines, sterols, and indole derivatives from the lithistid sponge Corallistes undulatus of the coral sea.  J. Nat. Prod.. 1993;  56 1962-70
  • 7 Fukuyama Y, Nakano Y, Pei-Wu G, Rui W, Sumitomo J, Jinxian B, Nakagawa K. In vitro Fibrinolytic Phytosterols Isolated from the Roots of Spatholobus suberetus .  Planta Med.. 1988;  54 34-6
  • 8 Gunstone F D. Fatty acids. In: Dey PM, Harborne JB eds Methods in Plant Biochemistry, Vol. 4, Lipids, Membranes and Aspects of Photobiology. London; Academic Press 1990
  • 9 De Kimpe N, Schamp N, Van Puyvelde L, Dubé S, Chagnon-Dubé M, Borremans F, Anteunis M JO, Declercq J -P, Germain G, Van Meerssche M. Isolation and structural identification of 8(14),15-sandaracopimaradiene-7α, 18-diol from Iboza riparia .  J. Org. Chem.. 1982;  47 3628-30
  • 10 Khalil A T, Gedara S R, Lahloub M F, Halim A F, Voehler M. A diterpene from Nepeta semptemcrenata .  Phytochemistry.. 1997;  44 475-8
  • 11 Van Puyvelde L, De Kimpe N, Borremans F, Zhang W, Schamp N. 8(14), 15-sandaracopimaradiene-2α,18-diol, a minor constituent of the Rwandese medicinal plant Tetradenia riparia. .  Phytochemistry.. 1987;  26 493-5
  • 12 Hui W H, Ng K K, Fukamiya N, Koreeda M, Nakanishi K. Isolation and structure of macarangonol, a diterpene ketol from Macaranga tanarius .  Phytochemistry.. 1971;  10 1617-20

Dr. A.-C. Mitaine-Offer

New address: Laboratoire de Pharmacognosie, Unité MIB, J E 2244

Faculté de Pharmacie

Université de Bourgogne

7, Bd. Jeanne D’Arc

BP 87900

21079 Dijon Cedex

France

Fax: 0033-3-80 39 33 00

eMail: acoffer@u-bourgogne.fr