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Synthesis 2002(8): 1072-1078
DOI: 10.1055/s-2002-31951
DOI: 10.1055/s-2002-31951
PAPER
© Georg Thieme Verlag Stuttgart · New York
An Efficient and Convenient Synthesis of 4-Vinylimidazoles Using a Novel Horner-Wadsworth-Emmons (HWE) Reagent: Synthetic Studies Toward Novel Histamine H3-Ligands
Weitere Informationen
Received
20 February 2002
Publikationsdatum:
03. Juni 2002 (online)
Publikationsverlauf
Publikationsdatum:
03. Juni 2002 (online)
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Abstract
A novel Horner-Wadsworth-Emmons (HWE)-type reagent 1 reacted readily with various aldehydes and ketones to produce (E)-vinylimidazoles 2 in good yields. The synthetic utility of 1 was demonstrated by the efficient preparation of four histamine H3 ligands 3 by simple hydrogenation of 2.
Key words
Horner-Wadsworth-Emmons reaction - vinylimidazole - hydrogenation - H3 ligands - immepip
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References
All yields are of the pure products after chromatography.