Planta Med 2002; 68(4): 307-310
DOI: 10.1055/s-2002-26752
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Cardiovascular Effects of Isorhamnetin and Quercetin in Isolated Rat and Porcine Vascular Smooth Muscle and Isolated Rat Atria

Manuel Ibarra2 , Francisco Pérez-Vizcaíno1 , Angel Cogolludo1 , Juan Duarte3 , Francisco Zaragozá-Arnáez1 , José Gustavo López-López1 , Juan Tamargo1
  • 1Department of Pharmacology, School of Medicine, University Complutense of Madrid, Madrid, Spain
  • 2Department of Pharmacology, School of Pharmacy, University of Alcalá, Madrid, Spain
  • 3Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain
Further Information

Publication History

June 19, 2001

October 7, 2001

Publication Date:
02 May 2002 (online)

Abstract

Isorhamnetin and quercetin produced endothelium-independent vasodilator effects in rat aorta, rat mesenteric arteries, rat portal vein and porcine coronary arteries. The effects of the two flavonoids were similar in arteries stimulated by noradrenaline, KCl, U46619 or phorbol esters but the two flavonoids were more potent in the coronary arteries than in the aorta. At high concentrations, they also induced a positive inotropic effect in isolated rat atria. Therefore, at least part of the in vivo effects of quercetin may result from its conversion to isorhamnetin which is the main metabolite of quercetin found in plasma. The arterial, venous and coronary vasodilator effects may contribute to the protective effects of flavonoids in ischaemic heart disease observed in epidemiological studies.

Abbreviations

cyclic AMP:Adenosine 3′:5′-cyclic monophosphate

cyclic GMP:Guanosine 3′:5′-cyclic monophosphate

Emax:Maximal effect

NO:Nitric oxide

pD2:Half-maximal effective concentration (as -log[M])

PMA:Phorbol 12-myristate-13-acetate

S.E.M.:Standard Error of the Mean

SIN-1:3-Morpholino-sydnonimine

SNP:Sodium nitroprusside

U46619:Thromboxane A2 mimetic

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Francisco Pérez Vizcaíno

Dept. Farmacología

Inst. Farmacología y Toxicología (CSIC)

Facultad de Medicina

Universidad Complutense

28040 Madrid

Spain

Phone: 34-913941472

Fax: 34-913941470

Email: fperez@ucmail.ucm.es