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Planta Med 2002; 68(4): 341-344
DOI: 10.1055/s-2002-26740
Original Paper
Biochemistry, Physiology, in vitro cultures
© Georg Thieme Verlag Stuttgart · New York

Evaluation of Podophyllum peltatum Accessions for Podophyllotoxin Production

Rita M. Moraes1 , Ebru Bedir1 , Holly Barrett1 , Charles Burandt Jr1 , Camilo Canel2 , Ikhlas A. Khan1, 3
  • 1National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi, USA
  • 2USDA, ARS, NPURU, National Center for Natural Products Research, University, Mississippi, USA
  • 3Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi, USA
Further Information

Publication History

June 21, 2001

August 19, 2001

Publication Date:
02 May 2002 (online)

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Abstract

In an effort to develop a sustainable source of podophyllotoxin for the production of anticancer drugs such as etoposide, teniposide and etopophos, Podophyllum peltatum accessions with podophyllotoxin-rich leaf biomass were identified and transplanted to different growing conditions by vegetative cuttings. Results indicate that the lignan profile in leaves does not change over time or due to environment conditions. Podophyllotoxin and α-peltatin content in the blades seems to be stable with an inverse relationship of concentration between these compounds. A podophyllotoxin-rich leaf accession showed low biosynthetic capability to synthesize α- and β-peltatin and the converse was also true, indicating that selection and cultivation of high-yielding podophyllotoxin leaf biomass may reduce production costs.

Key words

Podophyllotoxin - Podophyllum - Berberidaceae - etoposide - teniposide - aryltetralin lignans - peltatins

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Rita M. Moraes

NCNPR, School of Pharmacy

The University of Mississippi

University, MS 38677, USA

Phone: +1 (662) 915 1147

Fax: +1 (662) 915 7989

Email: rmoraes@olemiss.edu

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