Z Gastroenterol 2002; 40(4): 269-272
DOI: 10.1055/s-2002-25150
Kommentierte Referate
© Karl Demeter Verlag im Georg Thieme Verlag Stuttgart · New York

Das präemptive Behandlungskonzept der CMV-Infektion nach Lebertransplantation

The Concept of Preemptive Therapy for CMV Infection following Liver TransplantationC. Benz, T. Goeser
  • 1Abt. für Gastroenterologie, Medizinische Universitätsklinken Köln
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Publikationsverlauf

Publikationsdatum:
17. April 2002 (online)

Prospective Randomized Trial to Assess the Value of Preemptive Oral Therapy for CMV Infection Following Liver Transplantation.

Rayes N, Seehofer D, Schmidt CA, Oettle H, Müller AR, Steinmüller T, Settmacher U, Bechstein WO, Neuhaus P.

Transplantation 2001; 72: 881-885

Literatur

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  • 2 Winston. et al . Prevention of cytomegalovirus disease in transplant recipients.  Lancet. 1995;  346 69
  • 3 Drew. et al . Prevalence of resistance in patients receiving ganciclovir for serious cytomegalovirus infection.  J Infect Dis. 1991;  163 716
  • 4 Rosen. et al . Development of ganciclovir resistance during treatment of primary cytomegalovirus infection after liver transplantation.  Transplantation. 1997;  63 476
  • 5 Limaye. et al . Emergence of ganciclovir-resistant cytomegalovirus disease among recipients of solid-organ transplants.  Lancet. 2000;  356 645
  • 6 Kanj. et al . Cytomegalovirus infection following liver transplantation: Review of the literature.  Clin Infect Dis. 1996;  22 537
  • 7 Humar. et al . Clinical utility of quantitative cytomegalovirus viral load determination for predicting cytomegalovirus disease in liver transplant recipients.  Transplantation. 1999;  68 1305
  • 8 Kusne. et al . Cytomegalovirus pp65 antigenemia monitoring as a guide for preemptive therapy: a cost effetive strategy for prefention of cytomegalovirus disease in adult liver transplant recipients.  Transplantation. 1999;  68 1125
  • 9 Vivarelli. et al . Abstension from treatment of low-level pp65 cytomegalovirus antigenemia after liver transplantation: a prospective study.  Transplantation. 2000;  70 1183
  • 10 Caliendo. et al . Comparison of quantative and qualitative PCR assays for cytomegalovirus DNA in plasma.  J Clin Micobiol. 2001;  39 1334
  • 11 Gerna. et al . Human cytomegalovirus immediate-early mRNA detection by nucleic acid sequencebased amplification as a new parameter for preemptive therapy in bone marrow transplant recipients.  J Clin Microbiol. 2000;  381-845
  • 12 Goossens. et al . Diagnostic value of nuclei-acid-sequence-based-amplification for the detection of cytomegalovirus infection in renal and liver transplant recipients.  Intervirology. 1999;  42 373
  • 13 Benz. et al . Charakterisierung CMV-spezifischer zytotoxischer CD8+- T-Lymphozyten nach Lebertranplatation.  Z Gastroenterol. 2000;  39 115A
  • 14 Singhal. et al . Direct visualization and quantitation of cytomegalovirus specific CD8+ cytotoxic T-lymphocytes in liver tranplant patients.  Transplantation. 2000;  69 2251
  • 15 Engstrand. et al . Characterization of CMVpp65-specific CD8+ T lymphocytes using MHC tetramers in kidney transplant patients and healthy participants.  Transplantation. 2000;  69 2243

Dr. Christine Benz

Abt. für Gastroenterologie
Medizinische Universitätsklinken

Joseph-Stelzmann-Str. 9

50931 Köln