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Dtsch Med Wochenschr 2002; 127(15): 803-804
DOI: 10.1055/s-2002-25051
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© Georg Thieme Verlag Stuttgart · New York

Celecoxib[1]

CelecoxibR. Fux, K. Mörike, C. H. Gleiter
  • 1Abteilung Klinische Pharmakologie, Universitätsklinikum Tübingen
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Publikationsverlauf

9.11.2001

17.1.2002

Publikationsdatum:
12. April 2002 (online)

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Celecoxib (Celebrex®) (Abb. 1) ist ein selektiver Inhibitor der Cyclooxygenase 2 (COX-2), der zur Behandlung der Osteoarthrose und der chronischen Polyarthritis zugelassen wurde. Konventionelle saure nicht-steroidale Antirheumatika (NSAR) wie Diclofenac oder Ibuprofen hemmen beide COX-Isoformen (Abb. 2). Die Entwicklung selektiver COX-2-Inhibitoren beruht auf der Vorstellung, die bei Entzündungsvorgängen induzierte COX-2 zu hemmen und die für die Funktion verschiedener Organe relevante COX-1 intakt zu lassen [7] [12].

1 Dieser Beitrag wurde gefördert durch das BMBF (FKZ: 01EC0001)

Literatur

1 Dieser Beitrag wurde gefördert durch das BMBF (FKZ: 01EC0001)

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Dr. med. R. Fux,
Priv.-Doz. Dr. med. K. Mörike,
Prof. Dr. med. C.H. Gleiter

Abt. Klin. Pharmakologie Universitätsklinikum Tübingen

Otfried-Müller-Straße 45

72076 Tübingen

eMail: sekretariat.akp@med.uni-tuebingen.de

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