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DOI: 10.1055/s-2002-23139
© Georg Thieme Verlag Stuttgart · New York
Muscle Relaxing Activity of Hyssopus officinalis Essential Oil on Isolated Intestinal Preparations
Publikationsverlauf
April 3, 2001
September 22, 2001
Publikationsdatum:
25. März 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200203/lookinside/thumbnails/10.1055-s-2002-23139-1.jpg)
Abstract
The muscle relaxing activity of the essential oil of Hyssopus officinalis L. (Lamiaceae) and some of its main components (isopinocamphone, limonene and β-pinene) was studied on isolated preparations of guinea-pig and rabbit intestine. The essential oil and isopinocamphone inhibited the acetylcholine- and BaCl2-induced contractions in guinea-pig ileum in a concentration-dependent manner (IC50 42.4 μg/ml and 61.9 μg/ml to acetylcholine; 48.3 μg/ml and 70.4 μg/ml to BaCl2) whereas limonene or β-pinene left tissue contraction unchanged. In guinea-pig ileum H. officinalis essential oil also blocked the contractions induced by CaCl2. In isolated rabbit jejunum the essential oil reduced the amplitude of spontaneous movements and decreased the basal tone; neither haemoglobin, methylene blue, N ω-nitro-L-arginine methyl ester (L-NAME) or propranolol blocked the myorelaxant effect.
Key words
Hyssopus officinalis L. - Lamiaceae - essential oil - isopinocamphone - muscle relaxing activity
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Gabriela Mazzanti
Dipartimento di Farmacologia delle Sostanze Naturali e Fisiologia Generale
University ”La Sapienza„
P.le Aldo Moro,5
00185, Rome, Italy
Telefon: +39-06-4991-2903
Fax: +39-06-4991-2480
eMail: gabriela.mazzanti@uniroma1.it