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Horm Metab Res 2002; 34(2): 102-106
DOI: 10.1055/s-2002-20524
Original Clinical

© Georg Thieme Verlag Stuttgart · New York

Simplified Measurement of Insulin Sensitivity with the Minimal Model Procedure in Type 2 Diabetic Patients without Measurement of Insulinemia

A.  Pérez-Martin 1 , E.  Raynaud 1 , C.  Hentgen 1 , J.  Bringer 2 , J.  Mercier 1 , J.  F.  Brun 1
  • 1 Service Central de Physiologie Clinique, Unité CERAMM (Centre d’Exploration et de Réadaptation des Anomalies Métaboliques et Musculaires), Montpellier, France
  • 2 Service d’Endocrinologie, CHU Lapeyronie, Montpellier, France
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Publication History

18 June 2001

16 October 2001

Publication Date:
04 March 2002 (online)

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Abstract

This study aimed to evaluate a simplified minimal model protocol for measuring insulin sensitivity in mild and severe type 2 diabetes, considering that changes in serum insulin during an insulin-modified intravenous glucose tolerance test almost only reflect the insulin injection. Two groups of diabetics treated with high doses of antidiabetic agents were recruited. Mean insulin responses were calculated in group 1 (n = 30). In group 2 (n = 38), we compared insulin sensitivity (SI) obtained with reference protocol with SI calculated by a minimal model procedure including the theoretical average insulin profile determined in group 1, and with Homeostasis Model Assessment (HOMA-R). Additionally, the cost of each procedure was calculated. SI measured by the reference method strongly correlated with SI determined by the simplified protocol (r = 0.966, p < 0.0001), while no correlation was found with HOMA-R (r = - 0.349, NS). Reduction of cost for HOMA-R and simplified minimal model procedure were - 92 and - 81 %, respectively. This simplified and relative inexpensive protocol, using minimal model procedure without insulin measurement, accurately measures SI regardless of β-cell defect degree. This approach could be of interest when limits of validity of simple indexes are reached.

Key words

Insulin Resistance - Type 2 Diabetes - Minimal Model - Basal Indexes - HOMA

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Antonia Pérez-Martin, M.D.

CERAMM-CHU Lapeyronie

34 295 Montpellier Cedex 5 · France

Phone: + 33 (0) 4 67 33 82 84

Fax: + 33 (0) 4 67 33 89 86

Email: a-perez_martin@chu-montpellier.fr