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DOI: 10.1055/s-2002-20250
© Georg Thieme Verlag Stuttgart · New York
Furanoligularenone, an Eremophilane from Ligularia fischeri, Inhibits the LPS-Induced Production of Nitric Oxide and Prostaglandin E2 in Macrophage RAW264.7 Cells
Publikationsverlauf
March 29, 2001
June 10, 2001
Publikationsdatum:
22. Februar 2002 (online)
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Abstract
Furanoligularenone (1), a known eremophilane, was identified from Ligularia fischeri (Compositae) together with 3-oxo-8α-hydroxy-10αH-eremophila-1,7(11)-dien-12,8β-olide (2) and 3-oxo-8α-methoxy-10αH-eremophila-1,7(11)-dien-12,8β-olide (3), by its potent inhibition of LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW 264.7 cells. Compound 1 also suppressed the expression of iNOS and COX-2 mRNA and protein in a dose-dependent manner. Taken together, compound 1 inhibits the production of NO and PGE2 at the transcription of iNOS and COX-2 genes, and would be responsible for the anti-inflammatory activities of the Ligularia fischeri.
Key words
Ligularia fischeri - Compositae - furanoligularenone - nitric oxide - prostaglandin E2 - inducible nitric oxide synthase - cyclooxygenase-2 - NF-κB
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Dr. Jung Joon Lee
Anticancer Research Laboratory
Korea Research Institute of Bioscience and Biotechnology
P.O. Box 115
Yusong
Taejon 305-600
Korea
eMail: jjlee@mail.kribb.re.kr
Fax: +82-42-860-4595