Am J Perinatol 2002; 19(1): 001-008
DOI: 10.1055/s-2002-20175
ORIGINAL ARTICLE

Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Impact of Advanced Maternal Age on Pregnancy Outcome

Muhieddine A.-F. Seoud, Anwar H. Nassar, Ihab M. Usta, Ziad Melhem, Alia Kazma, Ali M. Khalil
  • Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon
Further Information

Publication History

Publication Date:
18 February 2002 (online)

ABSTRACT

The aim of this study was to compare the pregnancy outcome and delivery complications in women 40 years or older (cases) to that of women 20 to 30 years old (controls). Over a 5-year period, 319 cases had a singleton delivery in our institution. These women were compared with 326 controls. Parity was significantly higher in cases compared with controls (3.2 vs. 1.8). Advanced maternal age, compared with younger age, was associated with significantly higher rates of preterm delivery (16.0 vs. 8.0%), cesarean delivery (CS) (31.3 vs. 13.5%), and the occurrence of one or more antepartum complications (29.5 vs. 16.6%). When the two groups were subdivided according to parity, rates of preterm delivery, CS, preeclampsia, gestational diabetes, chronic hypertension, and labor induction were each significantly higher among older multiparas compared with control multiparas. However, only preterm delivery, CS rates, and uterine fibroids were found to be significantly higher in older nulliparous compared with young nulliparous women. We conclude that multiparous women at least 40 years old have a higher antepartum complication rate including intrauterine fetal death compared with younger women.

REFERENCES

  • 1 Kane S H. Advanced maternal age and the primigravida.  Obstet Gynecol . 1967;  29 409-414
  • 2 Hansen J P. Older maternal age and pregnancy outcome: a review of the literature.  Obstet Gynecol . 1986;  41 726-712
  • 3 Sauer M V, Paulson R J, Lobo R A. Pregnancy in women 50 or more years of age: outcomes of 22 consecutively established pregnancies from oocyte donation.  Fertil Steril . 1995;  64 11-15
  • 4 Sauer M V, Paulson R J, Lobo R A. Pregnancy after age 50: application of oocyte donation to women after natural menopause.  Lancet . 1993;  341 321-323
  • 5 Seoud M, Toner J P, Kruithoff C, Muasher S J. Outcome of twin, triplet and quadruplet IVF pregnancies: the Norfolk experience.  Fertil Steril . 1992;  57 825-834
  • 6 Bianco A, Stone J, Lynch L, Lapinsky R, Berkowitz G, Berlowitz R L. Pregnancy outcome at age 40 and older.  Obstet Gynecol . 1996;  87 917-922
  • 7 Dulitzki M, Soriano D, Schiff E, Chetrit A, Mashiach S, Seidman D S. Effect of very advanced maternal age on pregnancy outcome and rate of Cesarean delivery.  Obstet Gynecol . 1998;  92 935-939
  • 8 Naeye R L. Maternal age, obstetric complication, and the outcome of pregnancy.  Obstet Gynecol . 1983;  61 210-215
  • 9 Yassin S Y, Beydoun S N. Pregnancy outcome at greater than or equal to 20 weeks' gestation in women in their 40s: a case-control study.  J Reprod Med . 1988;  33 209-212
  • 10 Gilbert W M, Nesbitt T S, Danielsen B. Childbearing beyond age 40: pregnancy outcome in 24,032 cases.  Obstet Gynecol . 1999;  93 9-14
  • 11 Zahed L, Nabulsi M, Bou-Ghanem M, Usta I. Acceptance of prenatal diagnosis for genetic disorders in Lebanon.  Prenat Diagn . 1999;  19 1109-1112