Subscribe to RSS
DOI: 10.1055/s-2002-19873
© Georg Thieme Verlag Stuttgart · New York
Saponins-Mediated Potentiation of Cisplatin Accumulation and Cytotoxicity in Human Colon Cancer Cells
Publication History
December 28, 2000
May 24, 2001
Publication Date:
31 January 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200201/lookinside/thumbnails/10.1055-s-2002-19873-1.jpg)
Abstract
The triterpene saponins jenisseensosides A, B, C, D were found to increase the accumulation and cytotoxicity of the anticancer agent cisplatin in human colon tumor cells. These compounds are glycosides of quillaic acid whose fucose residue was acylated by a trans- or cis-p methoxycinnamic acid. In contrarst, other saponins derivatives without this acyl moiety were not found to potentiate the accumulation and cytotoxicity of cisplatin. These results suggested the importance of the acyl moiety for activity.
References
- 1 Assem M, Bonvalot S, Beltramo J L, Garrido C, Dimanche Boitrel M T, Genne P, Rebibou J M, Caillot D, Chauffert B. Deleterious effect of serum proteins on amphotericin B-induced potentiation of cisplatin in human colon cancer cells. British Journal of Cancer. 1994; 70 631-5
- 2 Lacaille-Dubois M A, Wagner H. A review of the biological and pharmacological activities of saponins. Phytomedicine. 1996; 2 363-86
-
3 Lacaille-Dubois M A, Wagner H. Bioactive saponins from plants: an update. In: Atta-Ur-Rahman, editor
Studies in Natural Products Chemistry, Bioactive Natural Products (Part B) . Amsterdam; Elsevier Vol. 21 2000: 633-87 -
4 Lacaille-Dubois M A. Biologically and pharmacologically active saponins from plants: recent advances. In: Oleszek W, Marston, A, editors
Saponins in Food, Feedstuffs and Medicinal Plants . Dordrecht, Boston, London; Kluwer Academic Publishers 2000: 205-18 - 5 Armah C N, Mackie A R, Roy C PK, Osbourn A E, Bowyer P, Ladha S. The membrane permeabilizating effect of avenacin A-1 involves the reorganization of bilayer cholesterol. Biophysical Journal. 1999; 76 281-90
- 6 Leng Y M, Ou Y J, Kwan C Y, Loh T T. Specific interaction between tetrandrine and Quillaja saponins in promoting permeabilisation of plasma membrane in human leukemic HL-60 cells. Biochimica et Biophysica Acta. 1997; 1325 318-28
- 7 Jekunen A P, Shalinsky D R, Hom D K, Albright K D, Heath D, Howell S. Modulation of cisplatin cytotoxicity by permeabilization of the plasma membrane by digitonin in vitro . Biochemical Pharmacology. 1993; 45 2079-85
- 8 Lacaille-Dubois M A, Hanquet B, Cui Z H, Lou Z C, Wagner H. Acylated triterpene saponins from Silene jenisseensis . Phytochemistry. 1995; 40 509-14
- 9 Lacaille-Dubois M A, Hanquet B, Cui Z H, Lou Z C, Wagner H. Jenisseensosides C and D, biologically active acylated triterpene saponins from Silene jenisseensis . Phytochemistry. 1997; 45 985-90
- 10 Lacaille-Dubois M A, Wagner H, Correia M, Chauffert B. Biological Screening of Plant Saponins on the Potentiation of the Cisplatin Cytotoxicity in Colon Cancer Cells. International Symposium Antitumour Products from Higher Plants Paris; 8 - 10 January 1998: 124
- 11 Marouf A, Desbene S, Khanh T C, Wagner H, Correia M, Chauffert B, Lacaille-Dubois M A. Triterpene saponins from the roots of Achyranthes bidentata . Pharmaceutical Biology,. 2001; 39 263-7
- 12 Melzig M F, Bader G, Loose R. Investigations of the mechanism of membrane activity of selected triterpenoid saponins. Planta Medica,. 2001; 67 43-8
Marie Aleth Lacaille-Dubois
Laboratoire de Pharmacognosie
Faculté de Pharmacie
Université de Bourgogne
7, Bd. Jeanne d’ Arc
BP 87900
21079 Dijon Cedex
France
Phone: +33-3-80393229
Fax: +33-3-80393300
Email: malacd@u-bourgogne.fr