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DOI: 10.1055/s-2002-19869
© Georg Thieme Verlag Stuttgart · New York
Antiplasmodial and Cytotoxic Activity of Galipinine and other Tetrahydroquinolines from Galipea officinalis
Publikationsverlauf
January 19, 2001
April 28, 2001
Publikationsdatum:
31. Januar 2002 (online)
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Abstract
The antimalarial and toxicological properties of four tetrahydroquinoline alkaloids from Galipea officinalis trunk bark were studied. Crude extracts and pure alkaloids were tested for in vitro antimalarial activity on Plasmodium falciparum. The IC50 were evaluated after 24 and 72 h contact between compounds and the parasite culture, and ranged from 1.8 to 40 μg/ml for the chloroquine-sensitive strain (CQS) and from 0.09 to 38 μg/ml for the chloroquine-resistant strains (CQR). Galipinine yielded the best antimalarial effect (IC50: 0.09 - 0.9 μg/ml on CQR strain) and this compound interacted particularly between the 32nd and the 40th hour of the P. falciparum erythrocytic cycle. The cytotoxicity of the extracts and pure tetrahydroquinoline alkaloids was assessed on the HeLa cell line and showed IC50 values ranging from 5.8 to above 50 μg/ml.
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Dr. Alexis Valentin
Laboratoire d’Immunologie et Parasitologie
UFR Sciences Pharmaceutiques
15, avenue Charles Flahault
F-34060 Montpellier Cedex 02
France
eMail: valentin@iup.pharma.univ-montp1.fr
Fax: +33 4-67-41-16-17