Planta Med 2002; 68(1): 68-69
DOI: 10.1055/s-2002-19869
Letter

© Georg Thieme Verlag Stuttgart · New York

Antiplasmodial and Cytotoxic Activity of Galipinine and other Tetrahydroquinolines from Galipea officinalis

Ingrid Jacquemond-Collet1 , Françoise Benoit-Vical2 , Mustofa  2, 3 , Alexis Valentin2 , Edouard Stanislas1 , Michèle Mallié2 , Isabelle Fourasté1
  • 1Laboratoire Pharmacophores Rédox, Phytochimie et Radiobiologie, Faculté des Sciences Pharmaceutiques, Toulouse, France
  • 2Laboratoire d’Immunologie et Parasitologie, UFR Sciences Pharmaceutiques, Montpellier, France
  • 3Laboratorium Farmakologi, Fakultas Kedokteran/Pusat Kedokteran Tropis, Universitas Gadjah Mada, Yogyakarta, Indonesia
Further Information

Publication History

January 19, 2001

April 28, 2001

Publication Date:
31 January 2002 (online)

Abstract

The antimalarial and toxicological properties of four tetrahydroquinoline alkaloids from Galipea officinalis trunk bark were studied. Crude extracts and pure alkaloids were tested for in vitro antimalarial activity on Plasmodium falciparum. The IC50 were evaluated after 24 and 72 h contact between compounds and the parasite culture, and ranged from 1.8 to 40 μg/ml for the chloroquine-sensitive strain (CQS) and from 0.09 to 38 μg/ml for the chloroquine-resistant strains (CQR). Galipinine yielded the best antimalarial effect (IC50: 0.09 - 0.9 μg/ml on CQR strain) and this compound interacted particularly between the 32nd and the 40th hour of the P. falciparum erythrocytic cycle. The cytotoxicity of the extracts and pure tetrahydroquinoline alkaloids was assessed on the HeLa cell line and showed IC50 values ranging from 5.8 to above 50 μg/ml.

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Dr. Alexis Valentin

Laboratoire d’Immunologie et Parasitologie

UFR Sciences Pharmaceutiques

15, avenue Charles Flahault

F-34060 Montpellier Cedex 02

France

Email: valentin@iup.pharma.univ-montp1.fr

Fax: +33 4-67-41-16-17