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Synthesis 2002(1): 0133-0137
DOI: 10.1055/s-2002-19313
DOI: 10.1055/s-2002-19313
PAPER
© Georg Thieme Verlag Stuttgart · New York
Efficient Syntheses of New CF3-containing Diazolopyrimidines
Further Information
Received
1 August 2001
Publication Date:
04 August 2004 (online)
Publication History
Publication Date:
04 August 2004 (online)
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Abstract
A new simple and efficient way to CF3-containing pyrimido[1,2-a]benzimidazole and pyrazolo[1,5-a]pyrimidines, by the reaction of 1,1,1-trifluoro-4-sulfonyl-but-3-ene-2,2-dioles 1a,b with aminoheterocycles is described. The influence of reaction conditions and nature of the aminoheterocycles on regiochemistry was investigated.
Key words
cycloaddition - heterocycles - pyrimido[1,2-a]benzimidazole - pyrazolo[1,5-a]pyrimidines - sulfones
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Krasovsky, A. L.; Nenajdenko, V. G.; Balenkova, E. S.; Synthesis 2001 in press.