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Synthesis 2002(1): 0075-0078
DOI: 10.1055/s-2002-19308
PAPER
© Georg Thieme Verlag Stuttgart · New York

Microwave Assisted Synthesis of 1,5-Disubstituted Hydantoins and Thiohydantoins in Solvent-Free Conditions

Satya Paul*a, Mukta Guptaa, Rajive Guptaa, André Loupyb
a Department of Chemistry, University of Jammu, Jammu-180 006, India
Fax: +91(191)505086; e-Mail: paul7@rediffmail.com;
b Laboratoire des Réactions Sélectives sur Supports, CNRS UMR 8615, Université Paris-Sud, 91405, Orsay, France
Fax: +33(169)154679; e-Mail: aloupy@icmo.u-psud.fr;
Further Information

Publication History

Received 28 June 2001
Publication Date:
04 August 2004 (online)

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Abstract

1,5-Disubstituted hydantoins/thiohydantoins 3a-p have been synthesized in 81-95% yield by a microwave-promoted solvent-free condensation of arylglyoxals 1 and phenylurea/thiourea 2 using PPE as a reaction mediator. This method can be extended towards the parallel synthesis of 3. The workup is simple and involves treatment with ice-cold water.

Key words

arylglyoxals - solvent-free conditions - polyphosphoric ester (PPE) - microwave activation - hydantoins

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