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Synthesis 2002(1): 0039-0042
DOI: 10.1055/s-2002-19291
DOI: 10.1055/s-2002-19291
PAPER
© Georg Thieme Verlag Stuttgart · New York
A Convenient Synthesis of p-Aminobenzyl-tris(hydroxymethyl)methane as Precursor of Solid-Supported Tripodal Ligands
Further Information
Received
25 July 2001
Publication Date:
04 August 2004 (online)
Publication History
Publication Date:
04 August 2004 (online)
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Abstract
p-Aminobenzyl-tris(hydroxymethyl)methane has been prepared in 5 steps from diethylmalonate and p-nitrobenzyl bromide, with an overall yield of 23%. This compound could be grafted on silica previously derivatized with 3-isocynatopropyltriethoxysilane.
Key words
tris(hydroxymethyl)methane derivatives - tripodal ligands - amino alcohols - solid-phase synthesis
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