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Synthesis 2001; 2001(1): 0081-0084
DOI: 10.1055/s-2001-9743
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Indium Mediated Reduction of Nitro and Azide Groups in the Presence of HCl in Aqueous Media

Jung Gyu Lee* , Kyung Il Choi, Hun Yeong Koh, Youseung Kim, Yonghan Kang, Yong Seo Cho
  • *Biochemicals Research Center, Korea Institute of Science and Technology, P. O. Box 131 Cheongryang, Seoul 130-650, Korea; Fax +82(2)9 58 51 89; E-mail: ys4049@kist.re.kr
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Publication Date:
31 December 2001 (online)

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Indium mediated reduction of azide and nitro groups in the presence of HCl (1.5 equiv based on indium) at room temperature in aqueous THF successfully provided the corresponding amine in high to quantitative yields. Under the same reaction conditions, selective reduction of azide and nitro group in the presence of vinyl group could be accomplished.

nitro compounds - azides - reductions - indium - amines