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Synlett 2001; 2001(1): 0160
DOI: 10.1055/s-2001-9729
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Crabtree's Catalyst: [Ir(cod)pyr(PCy3)]PF6

Peter G. Nell*
  • *Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA
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Publication History

Publication Date:
31 December 2001 (online)

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(1,5-Cyclooctadiene)(pyridine)(tricyclohexylphosphine)iridium(I) hexafluorophosphate 1 [Ir(cod)pyr(PCy3)]PF6, Crabtree's catalyst, is a versatile catalyst for selective hydrogenation and hydroboration. It was first introduced by Crabtree, Felkin and Morris for the hydrogenation of hindered olefins, whether or not activating groups are present. It was later discovered that selective hydrogen addition to one face of a chiral molecule was possible in the presence of a coordinating hydroxyl group. Evans and Fu first reported the use of Crabtree's catalyst in the catalytic directed hydroboration.