Planta Med 2001; 67(9): 867-870
DOI: 10.1055/s-2001-18845
Letter

© Georg Thieme Verlag Stuttgart · New York

Artelastocarpin and Carpelastofuran, Two New Flavones, and Cytotoxicities of Prenyl Flavonoids from Artocarpus elasticus against Three Cancer Cell Lines

Honorina M. Cidade1 , Maria São José Nacimento1 , Madalena M. M. Pinto1 , Anake Kijjoa2 , Artur M. S. Silva3 , Werner Herz4
  • 1 Centro de Estudos de Química Orgânica, Fitoquímica e Farmacologia de Universidade do Porto, Faculdade de Farmácia, Rua Anibal Cunha, Porto, Portugal
  • 2 Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Porto, Portugal
  • 3 Departamento de Química, Universidade de Aveiro, Aveiro, Portugal
  • 4 Department of Chemistry, The Florida State University, Tallahassee, FL, USA
Further Information

Publication History

December 8, 2000

March 6, 2001

Publication Date:
06 December 2001 (online)

Abstract

Further study of one of the fractions from the wood of Artocarpus elasticus furnished two new prenylated flavonoids artelastocarpin and carpelastofuran as well as ethyl 2,4-dihydroxybenzoate. The two flavonoids and the prenylated flavonoids artelastin, artelastochromene, artelasticin, artocarpesin, and cyclocommunin isolated earlier from this species were tested for cytotoxicity in vitro against three human cell lines. All seven flavonoids were active, the cytotoxic effect varying from strong to moderate and with artelastin showing the most potent activity.

References

  • 1 Kijjoa A, Cidade H M, Pinto M MM, Gonzalez M JTG, Anantachoke C, Gedris T E, Herz W. Prenylflavonoids from Artocarpus elasticus .  Phytochemistry. 1996;  43 691-4
  • 2 Kijjoa A, Cidade H M, Gonzalez M JTG, Afonso C M, Silva A MS, Herz W. Further prenylflavonoids from Artocarpus elasticus .  Phytochemistry. 1998;  47 875-8
  • 3 Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, Warren J T, Bokesch H, Kenney S, Boyd M R. New colorimetric cytotoxicity assay for anticancer-drug screening.  Journal of the National Cancer Institute. 1990;  82 1107-12
  • 4 Monks A, Scudiero D, Skehan P, Shoemaker R, Paull K, Vistica D, Hose C, Langley J, Cronise P, Vaigro-Wolff A, Gray-Goodrich M, Campbell H, Mayo J, Boyd M. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.  Journal of the National Cancer Institute. 1991;  83 757-66

Prof. Werner Herz

Department of Chemistry

The Florida State University

Tallahassee

FL 32306-4390

USA

Email: jdulin@chem.fsu.edr

Fax: +1-850-644-8281