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DOI: 10.1055/s-2001-18685
Long-Term Correction of Hyperglycaemia in Streptozotocin-Induced Diabetic Rats Transplanted with Islets Placed in an Implantation Device
Publication History
Publication Date:
04 December 2001 (online)
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Introduction
Pancreatic islet xenotransplantation might conceivably be successfully achieved if the islets are placed in a device protecting them against immune rejection [1]. We were interested in taking a first step in exploring this possibility using a rat model. The present study was aimed at monitoring the changes in body weight and glycemia occurring in streptozotocin-induced diabetic rats (STZ rats) transplanted with xenografted islets. Islets were prepared from animals of the same species and strain and placed in an implantation device with selectively permeable membranes.
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Prof. W. J. Malaisse
Laboratory of Experimental Medicine
Brussels Free University
808 Route de Lennik
1070 Brussels, Belgium
Phone: + 32 (2) 55 56 238
Fax: + 32 (2) 55 56 239
Email: malaisse@med.ulb.ac.be