Semin Respir Crit Care Med 2001; 22(5): 541-550
DOI: 10.1055/s-2001-18426
Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Organ Procurement-Strategies to Optimize Donor Availability

Trevor J. Williams1,2 , Gregory I. Snell1,2
  • 1Lung Transplant Service (Medical), Alfred Hospital, Prahran (Melbourne) Victoria, Australia
  • 2 Monash University, Melbourne, Victoria, Australia
Further Information

Publication History

Publication Date:
14 November 2001 (online)

ABSTRACT

Increasing donor availability for organ transplantation requires attention to factors that are potentially modifiable. The potential pool of available organs can theoretically be enlarged by considering new sources of organs, including non-beating heart donors, live donor lobar transplants, xenotransplants, and in vitro organ culture. Increased utilization of the current pool of organs can be achieved by creating a system that identifies, considers, and optimizes all possible donors. Although protocols have been drawn up regarding general and specifically lung donor acceptance criteria, many of these can be now recognized as unduly conservative and without a proven clinical basis. Careful reanalysis of these acceptance criteria and active donor management can be balanced against the particular circumstance of an individual potential recipient to increase lung transplantation rates.

REFERENCES

  • 1 Matesanz R, Miranda B. Organ donation: the ``Spanish model''.  Transplant Proc . 1996;  28(1) 11
  • 2 Australian and New Zealand Organ Registry. ANZOD 2000 Registry Report. Herbert K, Russ G, eds. 2000. Adelaide, Australia: Australian and New Zealand Organ Registry
  • 3 Australian Bureau of Statistics. Australian demographic statistics: ABS reference 3101.0. 12-1-1997
  • 4 Maurer J R, Frost A E, Estenne M, Higenbottam T, Glanville A R. International guidelines for the selection of lung transplant candidates. The International Society for Heart and Lung Transplantation, the American Thoracic Society, the American Society of Transplant Physicians, the European Respiratory Society.  J Heart Lung Transplant . 1998;  17(7) 703-709
  • 5 Jennett B, Gleave J, Wilson P. Brain death in three neurosurgical units.  British Medical Journal . 1981;  282 533-539
  • 6 Parisi F, Squitieri C, Carotti A, Di Carlo D, Gagliardi M G. Heart transplantation on the first day of life from an anencephalic donor [see comments].  Pediatr Transplant . 1999;  3(2) 150-151
  • 7 Heindl U T, Laub M C. Outcome of persistent vegetative state following hypoxic or traumatic brain injury in children and adolescents.  Neuropediatrics . 1996;  27(2) 94-100
  • 8 Childs N L, Mercer W N. Brief report: late improvement in consciousness after post-traumatic vegetative state.  N Engl J Med . 1996;  334(1) 24-25
  • 9 Lansman S, Ergin M, Griepp R. The History of Heart and Lung Transplantation. In: Shumway S, Shumway N, eds. Thoracic Transplantation Cambridge, Mass.: Blackwell Science 1995: 3-14
  • 10 Akasaka S, Nishi H, Aoe M, Date H, Andou A, Shimizu N. The effects of recombinant tissue-type plasminogen activator (rt-PA) on canine cadaver lung transplantation.  Surg Today . 1999;  29(8) 747-754
  • 11 Starnes V A, Woo M S, MacLaughlin E F. Comparison of outcomes between living donor and cadaveric lung transplantation in children.  Ann Thorac Surg . 1999;  68(6) 2279-2283
  • 12 Schmoeckel M, Nollert G, Shahmohammadi M. Transgenic human decay accelerating factor makes normal pigs function as a concordant species.  J Heart Lung Transplant . 1997;  16(7) 758-764
  • 13 Martin U, Steinhoff G, Kiessig V. Porcine endogenous retrovirus (PERV) was not transmitted from transplanted porcine endothelial cells to baboons in vivo.  Transpl Int . 1998;  11(4) 247-251
  • 14 Metcalf D. The colony stimulating factor (CSF).  Aust J Exp Biol Med Sci . 1972;  50(5) 547-557
  • 15 Michielsen P. Presumed consent to organ donation: 10 years' experience in Belgium.  J R Soc Med . 1996;  89(12) 663-666
  • 16 Manninen D L, Evans R W. Public attitudes and behavior regarding organ donation.  JAMA . 1985;  253(21) 3111-3115
  • 17 Caplan A L, Van Buren T C, Tilney N L. Financial compensation for cadaver organ donation: good idea or anathema.  Transplant Proc . 1993;  25(4) 2740-2742
  • 18 Frost A E. Donor criteria and evaluation.  Clin Chest Med . 1997;  18(2) 231-237
  • 19 Drinkwater D C, Laks H. Donor procurement and management. In: Kapoor AS, Laks H, Schroeder JS, Yacoub MH, eds. Cardiomyopathies and Heart-Lung Transplantation New York: McGraw-Hill, 1991: 173-184
  • 20 Little D M, Farrell J G, Cunningham P M, Hickey D P. Donor sepsis is not a contraindication to cadaveric organ donation.  QJM . 1997;  90(10) 641-642
  • 21 Shennib H, Adoumie R, Fraser R. Successful transplantation of a lung allograft from a carbon monoxide-poisoning victim.  J Heart Lung Transplant . 1992;  11(1 Pt 1) 68-71
  • 22 Conte J V, Ferber L R, Borja M. Lung transplantation from dialysis dependent donors.  J Heart Lung Transplant . 2000;  19(9) 894-896
  • 23 Van Thiel H D, De Maria N, Colantoni A, Friedlander L. Can hepatitis B core antibody positive livers be used safely for transplantation: hepatitis B virus detection in the liver of individuals who are hepatitis B core antibody positive.  Transplantation . 1999;  68(4) 519-522
  • 24 Bouthot B A, Murthy B V, Schmid C H, Levey A S, Pereira B J. Long-term follow-up of hepatitis C virus infection among organ transplant recipients: implications for policies on organ procurement.  Transplantation . 1997;  63(6) 849-853
  • 25 Cotler S J, Jensen D M, Kesten S. Hepatitis C virus infection and lung transplantation: a survey of practices.  J Heart Lung Transplant . 1999;  18(5) 456-459
  • 26 Weihl C C, Roos R P. Creutzfeldt-Jakob disease, new variant Creutzfeldt-Jakob disease, and bovine spongiform encephalopathy.  Neurol Clin . 1999;  17(4) 835-859
  • 27 Scornik J C, Zander D S, Baz M A, Donnelly W H, Staples E D. Susceptibility of lung transplants to preformed donor-specific HLA antibodies as detected by flow cytometry.  Transplantation . 1999;  68(10) 1542-1546
  • 28 Choi J K, Kearns J, Palevsky H I. Hyperacute rejection of a pulmonary allograft: immediate clinical and pathologic findings.  Am J Respir Crit Care Med . 1999;  160(3) 1015-1018
  • 29 Frost A E, Jammal C T, Cagle P T. Hyperacute rejection following lung transplantation.  Chest . 1996;  110(2) 559-562
  • 30 Fletcher C, Peto R. The natural history of chronic airflow obstruction.  Br Med J . 1977;  1(6077) 1645-1648
  • 31 Meyer D M, Bennett L E, Novick R J, Hosenpud J D. Effect of donor age and ischemic time on intermediate survival and morbidity after lung transplantation.  Chest . 2000;  118(5) 1255-1262
  • 32 Sundaresan S, Semenkovich J, Ochoa L. Successful outcome of lung transplantation is not compromised by the use of marginal donor lungs.  J Thorac Cardiovasc Surg . 1995;  109(6) 1075-1079
  • 33 Gabbay E, Williams T J, Griffiths A P. Maximizing the utilization of donor organs offered for lung transplantation.  Am J Respir Crit Care Med . 1999;  160(1) 265-271
  • 34 Fisher A J, Donnelly S C, Hirani N. Elevated levels of interleukin-8 in donor lungs is associated with early graft failure after lung transplantation.  Am J Respir Crit Care Med . 2001;  163(1) 259-265
  • 35 Jones S D, Fullerton D A, Zamora M R, Badesch D B, Campbell D N, Grover F L. Transmission of Lactobacillus pneumonia by a transplanted lung.  Ann Thorac Surg . 1994;  58(3) 887-889
  • 36 Deusch E, End A, Grimm M, Graninger W, Klepetko W, Wolner E. Early bacterial infections in lung transplant recipients.  Chest . 1993;  104(5) 1412-1416
  • 37 Zenati M, Dowling R D, Dummer J S. Influence of the donor lung on development of early infections in lung transplant recipients.  J Heart Transplant . 1990;  9(5) 502-508
  • 38 Liu B Q, Peto R, Chen Z M. Emerging tobacco hazards in China: 1. Retrospective proportional mortality study of one million deaths.  BMJ . 1998;  317(7170) 1411-1422
  • 39 Bhorade S M, Vigneswaran W, McCabe M A, Garrity E R. Liberalization of donor criteria may expand the donor pool without adverse consequence in lung transplantation.  J Heart Lung Transplant . 2000;  19(12) 1199-1204
  • 40 Corris P A, Dark J H. Aetiology of asthma: lessons from lung transplantation.  Lancet . 1993;  341(8857) 1369-1371
  • 41 Snell G I, Griffiths A, Macfarlane L. Maximizing thoracic organ transplant opportunities: the importance of efficient coordination.  J Heart Lung Transplant . 2000;  19(4) 401-407
  • 42 Davis Jr D R, Trulock E P, Manley J. Differences in early results after single-lung transplantation. Washington University Lung Transplant Group.  Ann Thorac Surg . 1994;  58(5) 1327-1334
  • 43 Ueno T, Smith J A, Snell G I. Bilateral sequential single lung transplantation for pulmonary hypertension and Eisenmenger's syndrome.  Ann Thorac Surg . 2000;  69(2) 381-387
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