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Synlett 2001; 2001(11): 1687-1689
DOI: 10.1055/s-2001-18095
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A Novel Proline-Catalyzed Three-Component Reaction of Ketones, Aldehydes, and Meldrum's Acid

Benjamin List* , Chris Castello
  • *Departments of Chemistry and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA; Fax + 1(858) 784 7028; E-mail: blist@scripps.edu
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Publication Date:
29 October 2001 (online)

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We describe a novel proline-catalyzed three-component domino reaction between ketones, aldehydes and Meldrum's acid. Two new carbon-carbon σ-bonds from three different components are formed in this efficient transformation.

multicomponent reactions - organocatalysis - C-C coupling - combinatorial chemistry - domino reactions