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Synlett 2001; 2001(10): 1653-1655
DOI: 10.1055/s-2001-17452
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One-pot Synthesis of Optically Active Tetramic Acids from Amino Acids Mediated by 1-Hydroxybenzotriazole

Giorgos Athanasellis* , Efstathios Gavrielatos, Olga Igglessi-Markopoulou
  • *Laboratory of Organic Chemistry, Department of Chemical Engineering, National Technical University of Athens, Zografou Campus, 15773 Athens, Greece; Fax + 30(1)7 72 30 72; E-mail: ojmark@orfeas.chemeng.ntua.gr
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Publication Date:
27 September 2001 (online)

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A novel synthesis of chiral 3-ethoxycarbonyl-5-substituted tetramic acids in moderate yields (45-75%) is reported. HPLC analysis of these tetramic acids shows very good enantiomeric excesses (82-98%).

tetramic acids - 1-hydroxybenzotriazole - natural products - amino acids