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Horm Metab Res 2001; 33(8): 463-466
DOI: 10.1055/s-2001-16938
Original Basic
© Georg Thieme Verlag Stuttgart · New York

Oxidation of D-[U -14C] Glucose and [1,12 -14C] Dodecanedioic Acid by Pancreatic Islets from Goto-Kakizaki Rats

W. J. Malaisse1 , M. Doherty1 , L. Ladrière1 , A. V. Greco2 , G. Mingrone2
  • 1 Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium
  • 2 Instituto de Clinica Medica, Universita Cattolica del Sacro Cuore, Roma, Italy
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Publikationsdatum:
04. September 2001 (online)

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In pancreatic islets from hereditarily diabetic GK rats, [1,12 -14C] dodecanedioic acid (5.0 mM) was oxidized at a rate representing about 5 % of that of D-[U - 14C] glucose (8.3 mM). Dioic acid and hexose failed to exert any significant reciprocal effects on their respective oxidation. The production of 14CO2 from [1,12 -14C] dodecanedioic acid was proportional to its concentration in the 0.2 - 5.0 mM range. These results were essentially comparable to those obtained in islets from control rats. They extend, therefore, to GK rats the knowledge that dodecanedioic acid acts as a nutrient in pancreatic islet cells.

Key words:

 [1,12 -14C] Dodecanedioic Acid - Pancreatic Islets - GK Rats

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W. J. Malaisse, M.D., Ph.D.

Laboratory of Experimental Medicine
Brussels Free University

808 Route de Lennik
1070 Brussels
Belgium


Telefon: + 32 (2) 5556237

Fax: + 32 (2) 5556239

eMail: malaisse@med.ulb.ac.be