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Planta Med 2001; 67(6): 567-569
DOI: 10.1055/s-2001-16492
Letter

© Georg Thieme Verlag Stuttgart · New York

Vasorelaxant Effects of the Bioflavonoid Chrysin in Isolated Rat Aorta

Juan Duarte1,*, Rosario Jiménez1 , Inmaculada Concepción Villar1 , Francisco Pérez-Vizcaíno2 , José Jiménez1 , Juan Tamargo2
  • 1 Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain
  • 2 Department of Pharmacology, School of Medicine, University Complutense of Madrid, Madrid, Spain
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Publikationsverlauf

August 4, 2000

January 28, 2001

Publikationsdatum:
17. August 2001 (online)

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Abstract

Chrysin relaxed the contractions induced by noradrenaline in isolated endothelium-intact rat aortic rings (IC50 = 16 ± 4 μM). Endothelium removal and N G-nitro-L-arginine methyl ester inhibited this relaxant effect. Chrysin potentiated the relaxation to acetylcholine under control conditions or after incubation with the superoxide anion generator hypoxanthine/xanthine oxidase. It also potentiated the relaxation induced by 3-morpholino-sydnonimine, sodium nitroprusside, and 8-bromoguanosine-3′:5′-cyclic-monophosphate. Therefore, vasorelaxation induced by chrysin in the rat aorta is endothelium- and NO-dependent. This effect is mediated by the prevention of O2 --induced inactivation of endothelial derived NO and also by the potentiation of cGMP-induced vasodilatation.

Abbreviations

L-NAME:N G-nitro-L-arginine methyl ester

NO:nitric oxide

SIN-1:3-morpholino-sydnonimine

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Dr. Juan Duarte

Department of Pharmacology

School of Pharmacy

University of Granada

18 071 Granada

Spain

eMail: jmduarte@ugr.es

Fax: +34-958-248964