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Synlett 2001; 2001(8): 1287-1289
DOI: 10.1055/s-2001-16054
DOI: 10.1055/s-2001-16054
letter
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α-Fluoromethyl Tryptophans via Imino Ene Reaction
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Publikationsverlauf
Publikationsdatum:
31. Dezember 2001 (online)
![](https://www.thieme-connect.de/media/synlett/200108/lookinside/thumbnails/10.1055-s-2001-16054-1.jpg)
A preparative simple synthesis of α-fluoromethyl tryptophans is described. The new method is based on a non-catalytic imine ene reaction of highly electrophilic imines derived from methyl bromodifluoro- and trifluoropyruvate, and 1-sulfonyl-3-methylene indolines.
α-fluoromethyl substituted α-amino acids - tryptophans - 3-methylene indoles - fluorinated imines - ene reactions