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Synlett 2001; 2001(8): 1197-1205
DOI: 10.1055/s-2001-16031
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From Arene-Catalyzed Lithiation to Other Synthetic Adventures

Miguel Yus*
  • *Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain; Fax + 34 965 90 35 49; E-mail: yus@ua.es
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Publication Date:
31 December 2001 (online)

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New processes based on an arene-catalyzed lithiation reaction include the fluorine-lithium exchange, the synthesis of cyclic polyethers, the structural modification of natural products such as carbohydrates or steroids, the generation of different functionalized organometallic intermediates by lithium-metal (copper, titanium) transmetallation, and the activation of nickel in order to get a simple methodology which allows the hydrogenation of different organic substrates without using molecular hydrogen. The synthetic applications of the developed methodology in all these reactions are emphasized along this account.

arene-catalyzed lithiation - functionalized organometallic intermediates - hydrogenation - cyclic polyethers - functionalized sugars and steroids