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Synlett 2001; 2001(7): 1173-1175
DOI: 10.1055/s-2001-15159
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A Solid-Phase Approach to Tetrahydrochromano[4,3-b]quinolines

Dawei Zhang* , Alexander S. Kiselyov
  • *Small Molecule Drug Discovery, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA; Fax + 1 (212) 645-20 54; E-mail: alexanderk@imclone.com
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Publication History

Publication Date:
31 December 2001 (online)

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A solid-phase synthesis of polysubstituted tetrahydrochromano[4,3-b]quinolines is described. These compounds are prepared by the reaction of immobilized anilines with the derivatives of salicylic aldehyde containing an electron-rich olefin substituent. This reaction is catalyzed by both 1%TFA and Yb(OTf)3. The targeted products are isolated as 1 : 1 mixtures of diastereomers.

solid-phase synthesis - combinatorial chemistry - imines - cycloadditions - quinolines