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Synlett 2001; 2001(7): 1097-1100
DOI: 10.1055/s-2001-15138
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Catalysis of 2- and 6- Substitution Reactions of Purines on Solid Phase

Wolfgang K.-D. Brill* , Claudia Riva-Toniolo, Sascha Müller
  • *Combinatorial Chemistry, Novartis Pharma AG, S-507.7.09, CH-4056-Basel, Switzerland; Fax + 41 61 696 83 60; E-mail: andreas.marzinzik@pharma.novartis.com
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Publication Date:
31 December 2001 (online)

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The synthesis of 2- and 6- disubstituted purines was accomplished using protic and Pd-mediated coupling reactions. Boronic acids and amines were successfully coupled under the same conditions.

purines - combinatorial chemistry - acid catalysis - Pd-mediated amination - arylations