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Horm Metab Res 2001; 33(4): 238-245
DOI: 10.1055/s-2001-14943
Original Clinical

© Georg Thieme Verlag Stuttgart · New York

Acute Plasma Volume Expansion in the Untrained Alters the Hormonal Response to Prolonged Moderate-Intensity Exercise

B. D. Roy1 , H. J. Green1 , S. M. Grant1 , M. A. Tarnopolsky2
  • 1 Dept. of Kinesiology, University of Waterloo, Waterloo, ON, Canada
  • 2 Dept. of Kinesiology and Medicine, McMaster University, Hamilton, ON, Canada
Further Information

Publication History

Publication Date:
31 December 2001 (online)

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To investigate the role of an increase in plasma volume (PV), characteristically observed with short-term endurance training, on the endocrine response to prolonged moderate intensity exercise, eight untrained males (V˙O2 peak = 3.52 ± 0.12 l × min-1) performed 90 min of cycle ergometry at approximately 60 % V˙O2peak both before (CON) and following (PVX) PV expansion. Acute PV expansion, which was accomplished using a solution of Dextran (6 %) or Pentispan (10 %) (6.7 ml kg-1), resulted in a calculated 15.8 ± 2.2 % increase (p < 0.05) in PV. The prolonged exercise resulted in increases (p < 0.05) in plasma vasopressin (AVP), plasma rennin activity (PRA), aldosterone (ALD), atrial naturetic peptide (α-ANP), and the catecholamines norepinephrine (NE) and epinephrine (EPI). PVX blunted the increases (p < 0.05) in AVP, PRA, ALD, NE and EPI, during the exercise itself. The concentration of α-ANP was also lower (p < 0.05) during exercise following PVX, an effect that could be attributed to the lower resting levels. No differences in osmolality was observed between conditions. These results demonstrate that PVX alters the fluid regulatory hormonal response in untrained subjects to moderate intensity dynamic exercise in a manner similar to that observed following short-term training induced alterations in PV. The specific mechanisms responsible for these alterations remain unclear, but appear to be related directly to the increase in PV.

Key words:

Plasma Volume - Aldosterone - Renin - Atrial Natriuretic Peptide - Norepinephrine - Epinephrine - Arginine Vasopressin

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Dr. H. J. Green

Department of Kinesiology
University of Waterloo

Waterloo, ON
Canada N2L 3G1


Phone: Phone:+ 1 (519) 888-4567, ext. 3454

Fax: Fax:+ 1 (519) 885-0470

Email: E-mail:green@healthy.uwaterloo.ca

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