Synlett 2001; 2001(Special Issue): 0986-0988
DOI: 10.1055/s-2001-14641
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Total Synthesis of cis,cis-Ceratospongamide, a Bioactive Thiazole-Containing Cyclic Peptide from Marine Origin

Fumiaki Yokokawa* , Hirofumi Sameshima, Takayuki Shioiri
  • *Faculty of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan; Fax + 81 (52) 8 34 41 72; E-mail: shioiri@phar.nagoya-cu.ac.jp
Further Information

Publication History

Publication Date:
31 December 2001 (online)

The first total synthesis of cis,cis-ceratospongamide (1a), isolated from marine source, was accomplished via thiazole synthesis using CMD methodology, DEPC-mediated peptide coupling, macrolactamization, and cyclodehydration. Comparison of the cyclization sites and coupling reagents in the macrolactamization step was also investigated.