Download PDF
Synlett 2001; 2001(6): 0863-0865
DOI: 10.1055/s-2001-14587
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Bismuth(III)-Catalyzed Synthesis of Dihydropyrimidinones: Improved Protocol Conditions for the Biginelli Reaction

K. Ramalinga* , P. Vijayalakshmi, T. N. B. Kaimal
  • *Oils & Fats Division, Indian Institute of Chemical Technology, Hyderabad-500-007, India; Fax + 91-40-7 17 33 70; E-mail: kaimal@iict.ap.nic.in
Further Information

Publication History

Publication Date:
31 December 2001 (online)

  PDF Download  Permissions and Reprints All articles of this category

An efficient synthesis of 3,4-dihydropyrimidines using bismuth chloride as a catalyst from an aldehyde, β-keto ester and urea in acetonitrile is described. Compared to the classical Biginelli reaction conditions, this new method consistently has the advantage of good yields (56-97%).

Biginelli reaction - dihydropyrimidinones - bismuth chloride - one-pot condensation - synthesis