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DOI: 10.1055/s-2001-13913
Uterine Receptivity in the Baboon: Modulation by Chorionic Gonadotropin
Publikationsverlauf
Publikationsdatum:
31. Dezember 2001 (online)
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ABSTRACT
Embryonic signals not only rescue the corpus luteum but also modulate the uterine environment in preparation for implantation. Chorionic gonadotropin (CG), an early embryonic signal, is one such molecule. In vivo studies in the baboon show that CG alters the morphology and biochemical activity of the uterus, especially with respect to the three major cell types: luminal epithelium, glandular epithelium, and stromal fibroblasts. Further, CG and progesterone have a synergistic effect on the receptive endometrium. CG action on the endometrial cells is transduced via a seven transmembrane G protein-coupled receptor. Possible signaling pathways involved are discussed.
KEYWORD
Uterus - chorionic gonadotropin - baboon
REFERENCES
- 1 Psychoyos A. Uterine receptivity for nidation. Ann N Y Acad Sci . 1968; 476 36-42
- 2 Bazer F W, Spencer T E, Ott T L. Interferon tau: a novel pregnancy recognition signal. Am J Immunol . 1997; 37 412-420
- 3 Geisert R D, Yelich J V. Regulation of conceptus development attachment in pigs. J Reprod Fertil Suppl . 1997; 52 133-149
- 4 Ghosh D, Sengupta J, Hendrickx A G. Effect of single-dose, early luteal phase administration of mifepristone (RU486) on implantation stage endometrium in the rhesus monkey. Hum Reprod . 1996; 11 2026-2035
- 5 Hild-Petito S, Donnelly K M, Miller J B, Verhage H G, Fazleabas A T. A baboon (Papio anubis) simulated pregnant model: cell specific expression of insulin-like growth factor binding protein-1 (IGFBP-1), type 1 IGF receptor (IGF-IR) and retinol binding protein (RBP) in the uterus. Endocrine . 1995; 3 639-651
- 6 Fazleabas A T, Donnelly K M, Srinivasan S, Fortman J D, Miller J B. Modulation of the baboon (Papio anubis) uterine endo by chorionic gonadotrophin during the period of uterine receptivity. Proc Natl Acad Sci U S A . 1999; 96 2453-2458
- 7 Ziecik A J, Stanchev P D, Telton J E. Evidence for the presence of luteinizing hormone/human chorionic gonadotrophin-binding sites in the porcine uterus. Endocrinology . 1986; 119 1159-1163
- 8 Jensen J D, Odell W D. Identification of LH/RCG receptors in rabbit uterus. Proc Soc Exp Biol Med . 1988; 189 28-30
- 9 Reshef E, Lei Z M, Rao C V, Pridham D D, Chegini N, Luborsky J L. The presence of gonadotropin receptors in non-pregnant human uterus, human placenta, fetal membrane and decidua. J Clin Endocrinol Metab . 1990; 70 421-430
- 10 Enders A C, Lantz K C, Peterson P E, Hendrickx A C. From blastocyst to placenta: the morphology of implantation in the baboon. Hum Reprod Update . 1997; 3 561-573
- 11 Enders A C. Current topic: structural responses of the primate endometrium to implantation. Placenta . 1991; 12 309-325
- 12 Tarara R, Enders A C, Hendrickx A G. Early implantation embryonic development of the baboon: stages 5, 6 and 7. Anat Embryol . 1987; 176 267-275
- 13 Bell S C, Hales M W, Patel S, Kirwan P H, Drife J O. Protein synchrony and secretion by the human endometrium and decidua during early pregnancy. Br J Obstet Gynaecol . 1985; 92 793-803
- 14 Hausermann H M, Donnelly K M, Bell S C, Verhage H G, Fazleabas A T. Regulation of the glycosylated beta-lactoglobulin homolog-glycodelin [placental protein 14 (pp14)] in the baboon (Papio anubis) uterus. J Clin Endocrinol Metab . 1998; 83 1226-1233
- 15 Christensen S, Verhage H G, Llovak G. Smooth muscle myosin II and alpha smooth muscle actin expression in the baboon (Papio anubis) uterus is associated with glandular secretory activity and stromal cell transformation. Biol Reprod . 1995; 53 598-608
- 16 Fazleabas A T, Bell S C, Fleming S, Sun V, Lessey B A. Distribution of integrins and the extracellular matrix proteins in the baboon endometrium during the menstrual cycle and early pregnancy. Biol Reprod . 1997; 56 348-356
- 17 Dedhar, Hannigan G E. Integrin cytoplasmic interactions and bidirectional transmembrane signaling. Curr Opin Cell Biol . 1996; 8 657-669
- 18 Gemzell-Danielsson K, Svalander P, Swahn M L, Johannisson E, Bygdeman M. Effects of a single post-ovulatory dose of RU486 on endometrial maturation in the implantation phase. Hum Reprod . 1994; 9 2398-2404
- 19 Marions L, Gemzell Danielsson K, Bygdeman M. The effect of antiprogestin on integrin expression in human endometrium: an immunohistochemical study. Mol Hum Reprod . 1998; 4 491-495
- 20 Ghosh D, Sengupta J, Hendrickx A G. Effect of single-dose, early luteal phase administration of mifepristone (RU486) on implantation stage endometrium in the rhesus monkey. Hum Reprod . 1996; 11 2026-2035
- 21 Nayak N R, Ghosh D, Sengupta J. Effects of luteal phase administration of mifepristone (RU486) and prostaglandin analogue or inhibitor on endometrium in the rhesus monkey. Hum Reprod . 1998; 13 1047-1056
- 22 Slayden O D, Zelinski-Wooten M B, Chwalisz K, Stouffer R L, Brenner R M. Chronic treatment of cycling rhesus monkeys with low doses of the antiprogestin ZK 137 316: morphometric assessment of the uterus and oviduct. Hum Reprod . 1998; 13 269-277
- 23 Banaszak S, Brudney A, Donnelly K, Chai D, Chwalisz K, Fazleabas A T. Modulation of the action of chorionic gonadotropin in the baboon (Papio anubis) uterus by a progesterone receptor antagonist (ZK 137.316). Biol Reprod . 2000; 63 820-825
- 24 Zelinski-Wooten M B, Chwalisz K, Iliff S A. A chronic, low-dose regimen of the antiprogestin ZK 137 316 prevents pregnancy in rhesus monkeys. Hum Reprod . 1998; 13 2132-2138
- 25 Zelinski-Wooten M B, Slayden O D, Chwalisz K, Hess D L, Brenner R M, Stouffer R L. Chronic treatment of female rhesus monkeys with low doses of the antiprogestin ZK 137.316: establishment of a regimen that permits normal menstrual cyclicity. Hum Reprod . 1998; 13 259-267
- 26 Cameron S T, Critchley H O, Thong K J, Buckley C H, Williams A R, Baird D T. Effects of daily low dose mifepristone on endometrial maturation and proliferation. Hum Reprod . 1996; 11 2518-2526
- 27 Brenner R M, Slayden O D. Cyclic changes in the primate oviduct and endometrium. In: Knobil E, Neill JD The Physiology of Reproduction. New York: Raven Press 1994: 541-569
- 28 Seppala M, Koistinen H, Koistinen R. Glycodelins as regulators of early events of reproduction. Clin Endocrinol . 1997; 46 381-386
- 29 Je T H, Ryu K-S, Gilchrist R, Ji I. Interaction, signal generation, signal divergence and signal transduction of LH/CG and the receptor. Recent Prog Horm Res . 1997; 52 431-454
- 30 Munir J, Fukunaga K, Miyazaki K, Okamura H, Miyamoto E. Mitogen-activated protein kinase activation and regulation of cyclooxygenase-2 expression by platelet-activated factor and hCG in human endometrial adenocarcinoma cell line HEC-1B. J Reprod Fertil . 1999; 117 49-59
- 31 Srisuparp S, Strakova Z, Luborsky J, Fazleabas A T. Signaling pathways activated by chorionic gonadotropin (CG) in the primate endometrium. Society for the Study of Reproduction, 33rd Annual Meeting, Madison, WI, 2000, abstract 33
- 32 Amsterdam A, Rosenberg R, Dantes A. Society for the Study of Reproduction, 33rd Annual Meeting, Madison, WI, 2000, abstract 34 .
- 33 Zhou X L, Lei Z M, Rao C V. Treatment of human endometrial gland epithelial cells with chorionic gonadotropin/ luteinizing hormone increases the expression of the cyclooxygenase-2 gene. J Clin Endocrinol Metab . 1999; 84 3364-3377
- 34 Han S W, Lei Z M, Rao C V. Treatment of human endometrial stromal cells with chorionic gonadotropin promotes their morphological and functional differentiation into decidua. Mol Cell Endocrinol . 1999; 147 7-16
- 35 Peng X, Kim J J, Fazleabas A T. Apoptosis and differentiation in baboon stromal cells: a role for chorionic gonadotropin (CG)?. Society for the Study of Reproduction, 33rd Annual Meeting, Madison, WI, 2000, abstract 510
- 36 Han S W, Lei Z M, Rao C V. Up-regulation of cyclooxygenase-2 gene expression by chorionic gonadotropin during the differentiation of human endometrial stromal cells into decidua. Endocrinology . 1996; 137 1791-1797
- 37 Nemansky M, Moy E, Lyons C D, Yu I, Blithe D L. Human endometrial stromal cells generate uncombined alpha-subunit from human chorionic gonadotropin, which can synergize with progesterone to induce decidualization. J Clin Endocrinol Metab . 1998; 83 575-581
- 38 Chabot V, Magallon T, Taragnat C, Combarnous Y. Two free isoforms of ovine glycoprotein hormone alpha-subunit strongly differ in their ability to stimulate prolactin release from foetal pituitaries. J Endocrinol . 2000; 164 287-297
- 39 Fazleabas A T, Kim J YJ, Donnelly K M, Verhage H. Embryo-maternal dialogue in the baboon (Papio anubis). In: Carson DD Embryo Implantation: Molecular, Cellular and Clinical Aspects. New York: Springer-Verlag 1999: 202-209