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Z Gastroenterol 2001; 39(5): 369-378
DOI: 10.1055/s-2001-13710
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© Karl Demeter Verlag im Georg Thieme Verlag Stuttgart · New York

Differenzielle Muzinexpression im Gastrointestinaltrakt

Differential mucin expression in the gastrointestinal tractM. Cornberg1 , M.-L. Enss2 , S. Wagner1
  • Abteilung Gastroenterologie und Hepatologie,
  • , Zentrales Tierlabor und Institut für Versuchstierkunde, Medizinische Hochschule Hannover, Hannover, Deutschland
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Publication History

10.10.2000

27.10.2000

Publication Date:
31 December 2001 (online)

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Zusammenfassung

Muzine zeigen im physiologischen Zustand ein gewebespezifisches Expressionsmuster. Die wichtigsten Muzingene im Gastrointestinaltrakt sind MUC2, MUC3, MUC5AC und MUC6. MUC2 und MUC3 werden vorwiegend im Darm exprimiert, MUC5AC und MUC6 im Magen.

Pathophysiologische Zustände sind durch eine aberrante Expression von gewebsunspezifischen Muzinen und/oder eine reduzierte Expression gewebsspezifischer Muzine gekennzeichnet.

Hierbei überwiegt bei entzündlichen Prozessen die Koexpression von gewebsunspezifischen Muzinen. Bei neoplastischen Veränderungen findet sich ebenfalls eine aberrante Muzinexpression. Offensichtlich sind die prognostisch günstigeren Formen mit einer hohen aberranten Expression nichtspezifischer Muzine assoziiert. Bei prognostisch ungünstigeren Neoplasien findet sich, anscheinend als Ausdruck einer fortschreitenden Entdifferenzierung, eine reduzierte Expression dieser Muzine.

Bei dieser veränderten Muzinexpression spielen nicht nur posttranskriptionelle Veränderungen eine Rolle, auch die Muzingene können hier unterschiedlich reguliert sein.

Eine modifizierte Muzinexpression lässt auf einen pathophysiologischen Zustand schließen und kann die pathohistologische Diagnostik ergänzen.

Abkürzungen: MUC: Muzingen; NTR: non-tandem repeat; TR: tandem repeat

Differential mucin expression in the gastrointestinal tract

Under physiological conditions mucins display a tissue specific expression. MUC2, MUC3, MUC5AC and MUC6 are the major mucins in the gastrointestinal tract. In the intestinal tissue MUC2 and MUC3 are the predominant mucins, whereas MUC5AC and MUC6 are the most important mucins in the stomach.

Pathophysiological conditions are characterized by an aberrant gene expression. This includes the expression of non-tissue specific mucins as well as a reduced expression of the specific mucins. During inflammation a co-expression of non-tissue specific mucins was observed. Neoplastic transformations are also associated with an aberrant mucin expression. Obviously, an increased expression of non-specific mucins is related with a more favorable prognosis, while a decreased mucin expression is indicative for an increased cellular dedifferentiation and a poor prognosis. This modified mucin expression may result from a modified gene expression as well as from modifications in the posttranscriptional processing.

A modified mucin expression reflects pathophysiological conditions and may support the pathohistological diagnosis.

Abbreviations: MUC: Mucin Gene, NTR Non-tandem Repeat, TR Tandem Repeat

Schlüsselwörter

Muzine - MUC-Gene - Gastrointestinaltrakt - gastrointestinale Tumoren

Key words

Mucins - MUC-Genes - Gastrointestinal Tract - Gastrointestinal Neoplasia

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Anschrift für die Verfasser

Dr. Markus Cornberg

Abteilung Gastroenterologie and Hepatologie
Medizinische Hochschule Hannover

30623 Hannover

Email: cornberg@gmx.de