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DOI: 10.1055/s-2001-13710
Differenzielle Muzinexpression im Gastrointestinaltrakt
Differential mucin expression in the gastrointestinal tractPublikationsverlauf
10.10.2000
27.10.2000
Publikationsdatum:
31. Dezember 2001 (online)
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Zusammenfassung
Muzine zeigen im physiologischen Zustand ein gewebespezifisches Expressionsmuster. Die wichtigsten Muzingene im Gastrointestinaltrakt sind MUC2, MUC3, MUC5AC und MUC6. MUC2 und MUC3 werden vorwiegend im Darm exprimiert, MUC5AC und MUC6 im Magen.
Pathophysiologische Zustände sind durch eine aberrante Expression von gewebsunspezifischen Muzinen und/oder eine reduzierte Expression gewebsspezifischer Muzine gekennzeichnet.
Hierbei überwiegt bei entzündlichen Prozessen die Koexpression von gewebsunspezifischen Muzinen. Bei neoplastischen Veränderungen findet sich ebenfalls eine aberrante Muzinexpression. Offensichtlich sind die prognostisch günstigeren Formen mit einer hohen aberranten Expression nichtspezifischer Muzine assoziiert. Bei prognostisch ungünstigeren Neoplasien findet sich, anscheinend als Ausdruck einer fortschreitenden Entdifferenzierung, eine reduzierte Expression dieser Muzine.
Bei dieser veränderten Muzinexpression spielen nicht nur posttranskriptionelle Veränderungen eine Rolle, auch die Muzingene können hier unterschiedlich reguliert sein.
Eine modifizierte Muzinexpression lässt auf einen pathophysiologischen Zustand schließen und kann die pathohistologische Diagnostik ergänzen.
Abkürzungen: MUC: Muzingen; NTR: non-tandem repeat; TR: tandem repeat
Differential mucin expression in the gastrointestinal tract
Under physiological conditions mucins display a tissue specific expression. MUC2, MUC3, MUC5AC and MUC6 are the major mucins in the gastrointestinal tract. In the intestinal tissue MUC2 and MUC3 are the predominant mucins, whereas MUC5AC and MUC6 are the most important mucins in the stomach.
Pathophysiological conditions are characterized by an aberrant gene expression. This includes the expression of non-tissue specific mucins as well as a reduced expression of the specific mucins. During inflammation a co-expression of non-tissue specific mucins was observed. Neoplastic transformations are also associated with an aberrant mucin expression. Obviously, an increased expression of non-specific mucins is related with a more favorable prognosis, while a decreased mucin expression is indicative for an increased cellular dedifferentiation and a poor prognosis. This modified mucin expression may result from a modified gene expression as well as from modifications in the posttranscriptional processing.
A modified mucin expression reflects pathophysiological conditions and may support the pathohistological diagnosis.
Abbreviations: MUC: Mucin Gene, NTR Non-tandem Repeat, TR Tandem Repeat
Schlüsselwörter
Muzine - MUC-Gene - Gastrointestinaltrakt - gastrointestinale Tumoren
Key words
Mucins - MUC-Genes - Gastrointestinal Tract - Gastrointestinal Neoplasia
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Anschrift für die Verfasser
Dr. Markus Cornberg
Abteilung Gastroenterologie and Hepatologie
Medizinische
Hochschule Hannover
30623 Hannover
eMail: cornberg@gmx.de