RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000083.xml
Synlett 2001; 2001(4): 0473-0476
DOI: 10.1055/s-2001-12329
DOI: 10.1055/s-2001-12329
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
Stereochemical Assignment and Stereoselective Synthesis of 3′-C-P-N-5′ R P-Ethyl Phosphonamidate Modified Nucleic Acid
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
31. Dezember 2001 (online)
![](https://www.thieme-connect.de/media/synlett/200104/lookinside/thumbnails/10.1055-s-2001-12329-1.jpg)
The configuration of the duplex stabilising 3′-C-P-N-5′ ethyl phosphonamidate nucleic acid backbone modification has been identified as R P following the preparation of cyclic nucleoside analogues and NOF studies. Complimentary routes for formation of the key phosphonamidate nitrogen to phosphorus bond from stereochemically defined H-phosphinate intermediates, involving both a retention and inversion at the phosphours centre, have been identified.
antisense - modified oligonucleotides - phosphorus protecting groups - stereoselective