PDF herunterladen
Synlett 2001; 2001(4): 0477-0480
DOI: 10.1055/s-2001-12323
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Preparation of Functionalized Magnesiated Aniline Derivatives

Greta Varchi* , Anne Eeg Jensen, Wolfgang Dohle, Alfredo Ricci, Gérard Cahiez, Paul Knochel
  • *Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, Haus F, 81377 München, Germany; Fax + 49-89-21 80 76 80; E-mail: knoch@cup.uni-muenchen.de
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 2001 (online)

  als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

Functionalized magnesiated aniline derivatives were readily prepared by using a bromine- or iodine-magnesium exchange. Formamidine or benzimine were found to be excellent protecting groups of the amino function for the generation of functionalized aminated Grignard reagents. These organomagnesium reagents react with various electrophiles such as aldehydes, iodoenones and allylic halides in excellent yields. After transmetallation with ZnBr2, Pd(0)-catalyzed cross-coupling with aryl iodides can be readily performed.

magnesium - heterocycles - bromine-magnesium exchange - cross-coupling reactions