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Synthesis 2001; 2001(3): 0478-0482
DOI: 10.1055/s-2001-11449
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Efficient Synthesis of N-3-Substituted 6-Aminouracil Derivatives via N 6-[(Dimethylamino)methylene] Protection

Eva-María Priego* , Marí-José Camarasa, María-Jesús Pérez-Pérez
  • *Instituto de Química Médica (C.S.I.C.), Juan de la Cierva 3, E-28006 Madrid, Spain; Fax + 34-91-5 64 48 53; E-mail: mjperez@iqm.csic.es
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Publication Date:
31 December 2001 (online)

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A convenient synthetic procedure has been developed to introduce different functional groups at position 3 of 6-amino-1-benzyl- or 6-amino-1-methyluracil based on N 6-[(dimethylamino)methylene] protection. This method allows for the smooth substitution at N-3 even when base-labile or heat sensitive halide reagents are employed.

alkylations - heterocycles - protecting groups - nucleobases