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Synlett 2001; 2001(3): 0406-0408
DOI: 10.1055/s-2001-11416
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Highly Enantioselective Cyclopropanation in Alcoholic and Aqueous Solvents Catalyzed by Optically Active β-Ketoiminato Cobalt(II) Complex

Taketo Ikeno* , Asae Nishizuka, Mitsuo Sato, Tohru Yamada
  • *Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan; Fax + 81(45)5 66 17 16; E-mail: yamada@chem.keio.ac.jp
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Publication Date:
31 December 2001 (online)

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The highly enantioselective cyclopropanation of styrenes and diazoacetates proceeded in alcohol or aqueous alcohol in the presence of the β-ketoiminato cobalt(II) complex. Water and alcohols accelerated the reaction and improved the diastereo- and enantioselectivities. In these media, the α,α-disubstituted styrenes were smoothly cyclopropanated with high enantiomeric excess.

asymmetric synthesis - cyclopropanation - water - alcohols - cobalt